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@ARTICLE{Krilaviciute:143172,
      author       = {A. Krilaviciute$^*$ and M. Leja and A. Kopp-Schneider$^*$
                      and O. Barash and S. Khatib and H. Amal and Y. Y. Broza and
                      I. Polaka and S. Parshutin and A. Rudule and H. Haick and H.
                      Brenner$^*$},
      title        = {{A}ssociations of diet and lifestyle factors with common
                      volatile organic compounds in exhaled breath of average-risk
                      individuals.},
      journal      = {Journal of breath research},
      volume       = {13},
      number       = {2},
      issn         = {1752-7163},
      address      = {Bristol},
      publisher    = {IOP},
      reportid     = {DKFZ-2019-00771},
      pages        = {026006},
      year         = {2019},
      abstract     = {Detection of diseases via exhaled breath remains an
                      attractive idea despite persisting gaps in understanding the
                      origin of volatile organic compounds (VOCs) and their
                      relationship with the disease of interest. Data on factors
                      potentially influencing the results of breath analysis
                      remain rather sparse and often controversial. In this study,
                      we aimed to investigate the associations of common VOCs in
                      exhaled breath of average-risk individuals with
                      socio-demographic and lifestyle factors, medical conditions
                      as well as diet.Alveolar breath samples of 1447 men and
                      women were collected in the morning after fasting and were
                      analyzed using gas-chromatography linked with
                      mass-spectrometry. Study participants were 40-64 years old,
                      cancer-free, with overall good health status. The
                      associations between selected VOCs and various factors
                      determined from the questionnaire data were assessed using
                      two-part-Wilcoxon test and Jonckheere-Terpstra trend
                      test.Fifteen VOCs where each of them was detected in at
                      least $80\%$ of the study population were included in this
                      analysis. Statistically significant associations with
                      various VOCs were demonstrated for gender and consumption of
                      certain foods, such as coffee, leeks and garlic, while
                      smoking was not associated with any of the analyzed
                      compounds.Factors potentially modifying the composition of
                      exhaled breath, such as dietary factors, deserve careful
                      attention in the design and analysis of studies accessing
                      the use of VOCs as diagnostic markers.},
      cin          = {C070 / C120 / C060 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)C060-20160331 / I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30523935},
      doi          = {10.1088/1752-7163/aaf3dc},
      url          = {https://inrepo02.dkfz.de/record/143172},
}