%0 Journal Article
%A Pletsch-Borba, Laura
%A Grafetstätter, Mirja
%A Hüsing, Anika
%A González Maldonado, Sandra
%A Kloss, Manja
%A Groß, Marie-Luise
%A Johnson, Theron
%A Sookthai, Disorn
%A Bugert, Peter
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study.
%J Scientific reports
%V 9
%N 1
%@ 2045-2322
%C [London]
%I Macmillan Publishers Limited, part of Springer Nature
%M DKFZ-2019-00786
%P 3004
%D 2019
%X Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30816120
%2 pmc:PMC6395643
%R 10.1038/s41598-018-38259-y
%U https://inrepo02.dkfz.de/record/143187