TY  - JOUR
AU  - Pletsch-Borba, Laura
AU  - Grafetstätter, Mirja
AU  - Hüsing, Anika
AU  - González Maldonado, Sandra
AU  - Kloss, Manja
AU  - Groß, Marie-Luise
AU  - Johnson, Theron
AU  - Sookthai, Disorn
AU  - Bugert, Peter
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Biomarkers of vascular injury in relation to myocardial infarction risk: A population-based study.
JO  - Scientific reports
VL  - 9
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2019-00786
SP  - 3004
PY  - 2019
AB  - Little is known about circulating biomarkers of vascular injury in relation to cardiovascular disease risk. Thus, we evaluated associations between six novel markers (E-Selectin, P-Selectin, thrombomodulin, thrombopoietin, intercellular adhesion molecule 3 and GPIIb/IIIa) and established cardiovascular risk factors as well as the risk of myocardial infarction (MI) in a population-based study. Biomarkers were measured in pre-diagnostic plasma samples of a case-cohort subset of EPIC-Heidelberg (incident MI cases: n = 369, random sub-cohort: n = 2,418). Generalized Linear models were used to analyse cross-sectional associations between biomarkers and cardiovascular risk factors. Multivariable Cox Regression analyses were carried out to obtain Hazard Ratios (HRs) of MI across quartiles of biomarkers levels. Cross-sectional analyses showed that sex, smoking, alcohol consumption, diabetes and exogenous hormone use were associated with biomarker levels. However, while fibrinogen was associated with MI risk (HR per standard deviation: 2.97 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:30816120
C2  - pmc:PMC6395643
DO  - DOI:10.1038/s41598-018-38259-y
UR  - https://inrepo02.dkfz.de/record/143187
ER  -