% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Boehlen:143207,
      author       = {F. H. Boehlen and J. Freigofas and W. Herzog and A. D. Meid
                      and K.-U. Saum$^*$ and B. Schoettker$^*$ and H. Brenner$^*$
                      and W. E. Haefeli and B. Wild},
      title        = {{E}vidence for underuse and overuse of antidepressants in
                      older adults: {R}esults of a large population-based study.},
      journal      = {International journal of geriatric psychiatry},
      volume       = {34},
      number       = {4},
      issn         = {1099-1166},
      address      = {Chichester [u.a.]},
      publisher    = {Wiley},
      reportid     = {DKFZ-2019-00806},
      pages        = {539 - 547},
      year         = {2019},
      abstract     = {Depression is common among elderly people. However,
                      diagnosis and adequate treatment is frequently difficult.
                      Research on underuse and overuse of antidepressants in
                      elderly persons is scarce. This study investigates the
                      utilization and appropriateness of pharmacological and
                      psychological depression treatment in a large cohort of
                      community-dwelling adults.A subsample of 3117 participants
                      (aged 55-85 y) of the third follow-up (2008-2010) of the
                      large population-based German ESTHER study was included.
                      Depression was assessed using the eight-item Patient Health
                      Questionnaire (PHQ-8). In the course of a home visit, study
                      doctors collected complete information on medication.
                      Logistic regression analyses were conducted to determine the
                      relationship of depression with both underuse and overuse of
                      antidepressants. The analyses were then adjusted for
                      socioeconomic variables, psychosomatic comorbidities, and
                      motivation to seek help.One hundred sixty-three participants
                      $(5.2\%;$ $95\%$ confidence interval [CI], 4.5-6.1)
                      fulfilled the criteria for major depression. Underuse of
                      antidepressants was present in 126 depressed participants
                      $(77.3\%;$ 70.1-83.5). Persons who were motivated to seek
                      help, who had an established depression diagnosis, or who
                      were taking more than five different medications had lower
                      odds of underuse. Anxiety was associated with higher odds
                      for underuse. Overuse of antidepressants (prescription
                      without clinical indication) was found in 96 cases
                      $(41.7\%;$ 35.3-48.4) of all antidepressant
                      prescriptions.Depression treatment in older adults is
                      frequently insufficient; it appears to depend on diagnosis
                      as well as the patients' motivation to seek help. Education
                      regarding the diagnosis of depression in the elderly as well
                      as guidelines for appropriate treatment is needed.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30623499},
      doi          = {10.1002/gps.5047},
      url          = {https://inrepo02.dkfz.de/record/143207},
}