TY  - JOUR
AU  - Goeppert, Benjamin
AU  - Truckenmueller, Felicia
AU  - Ori, Alessandro
AU  - Fritz, Valerie
AU  - Albrecht, Thomas
AU  - Fraas, Angelika
AU  - Scherer, Dominique
AU  - Silos, Rosa González
AU  - Sticht, Carsten
AU  - Gretz, Norbert
AU  - Mehrabi, Arianeb
AU  - Bewerunge-Hudler, Melanie
AU  - Pusch, Stefan
AU  - Bermejo, Justo Lorenzo
AU  - Dietrich, Peter
AU  - Schirmacher, Peter
AU  - Renner, Marcus
AU  - Roessler, Stephanie
TI  - Profiling of gallbladder carcinoma reveals distinct miRNA profiles and activation of STAT1 by the tumor suppressive miRNA-145-5p.
JO  - Scientific reports
VL  - 9
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Macmillan Publishers Limited, part of Springer Nature
M1  - DKFZ-2019-00824
SP  - 4796
PY  - 2019
AB  - Gallbladder carcinoma (GBC) is a biliary tract cancer with few treatment options and poor prognosis. Radical surgery is the only potentially curative treatment option but most patients diagnosed with GBC are unresectable. Thus, there is a great need for the development of new treatment options including targeted therapy. Here, we aimed at identifying deregulated miRNAs and affected pathways involved in GBC development and progression. We performed global miRNA profiling of 40 GBC and 8 normal gallbladder tissues and identified large differences with 30
LB  - PUB:(DE-HGF)16
C6  - pmid:30886199
C2  - pmc:PMC6423323
DO  - DOI:10.1038/s41598-019-40857-3
UR  - https://inrepo02.dkfz.de/record/143225
ER  -