TY  - JOUR
AU  - Joisten, Niklas
AU  - Rademacher, Annette
AU  - Bloch, Wilhelm
AU  - Schenk, Alexander
AU  - Oberste, Max
AU  - Dalgas, Ulrik
AU  - Langdon, Dawn
AU  - Caminada, Daniel
AU  - Purde, Mette-Triin
AU  - Gonzenbach, Roman
AU  - Kool, Jan
AU  - Zimmer, Philipp
AU  - Bansi, Jens
TI  - Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS - study protocol of a randomized controlled trial.
JO  - BMC neurology
VL  - 19
IS  - 1
SN  - 1471-2377
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2019-00826
SP  - 37
PY  - 2019
AB  - Studies have shown positive effects of therapeutic exercise on motor- and cognitive function as well as on psychosocial outcomes in persons with multiple sclerosis (MS). A reduction of inflammatory stress through physical exercise has been suspected as one key mechanism, mediating the positive effects of exercise in the context of MS. The primary objective of this trial is to investigate the acute and chronic effects of different exercise modalities on (anti-)inflammatory immune signalling as well as on cognitive and functional capacity in persons with MS.A two armed single-blind randomized controlled design will investigate 72 persons with relapsing remitting or secondary progressive MS (EDSS 3.0-6.0), during 3 weeks of inpatient rehabilitation. Participants will be randomized into either a high-intensity interval training (HIIT) or a moderate continuous training group; the latter represents the local standard therapy (ST). Both groups will exercise 3x per week. The HIIT group will perform 5 × 1.5-min high-intensive exercise bouts at 95-100
LB  - PUB:(DE-HGF)16
C6  - pmid:30849952
C2  - pmc:PMC6407211
DO  - DOI:10.1186/s12883-019-1267-9
UR  - https://inrepo02.dkfz.de/record/143227
ER  -