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000143244 041__ $$aeng
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000143244 1001_ $$00000-0001-9044-0744$$aVissers, Linda E T$$b0
000143244 245__ $$aDairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study.
000143244 260__ $$aAlexandria, Va.$$bAssoc.$$c2019
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000143244 520__ $$aTo estimate the causal association between intake of dairy products and incident type 2 diabetes.The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression.Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95% CI 10.6-23.6) and milk beverages (β 2.8 g/day, 95% CI 1.0-4.5) but not with intake of other dairy products. Other dietary intakes associated with rs4988235 included fruits (β -7.0 g/day, 95% CI -12.4 to -1.7 per additional LP allele), nonalcoholic beverages (β -18.0 g/day, 95% CI -34.4 to -1.6), and wine (β -4.8 g/day, 95% CI -9.1 to -0.6). In instrumental variable analysis, LP-associated milk intake was not associated with diabetes (hazard ratioper 15 g/day 0.99, 95% CI 0.93-1.05).rs4988235 was associated with milk intake but not with intake of other dairy products. This MR study does not suggest that milk intake is associated with diabetes, which is consistent with previous observational and genetic associations. LP may be associated with intake of other foods as well, but owing to the modest associations, we consider it unlikely that this caused the observed null result.
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000143244 7001_ $$00000-0001-7758-4911$$aSluijs, Ivonne$$b1
000143244 7001_ $$avan der Schouw, Yvonne T$$b2
000143244 7001_ $$00000-0002-5041-248X$$aForouhi, Nita G$$b3
000143244 7001_ $$aImamura, Fumiaki$$b4
000143244 7001_ $$aBurgess, Stephen$$b5
000143244 7001_ $$aBarricarte, Aurelio$$b6
000143244 7001_ $$aBoeing, Heiner$$b7
000143244 7001_ $$aBonet, Catalina$$b8
000143244 7001_ $$aChirlaque, Maria-Dolores$$b9
000143244 7001_ $$00000-0001-5033-5966$$aFagherazzi, Guy$$b10
000143244 7001_ $$00000-0002-0520-7604$$aFranks, Paul W$$b11
000143244 7001_ $$aFreisling, Heinz$$b12
000143244 7001_ $$aGunter, Marc J$$b13
000143244 7001_ $$aQuirós, J Ramón$$b14
000143244 7001_ $$aIbsen, Daniel B$$b15
000143244 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b16$$udkfz
000143244 7001_ $$aKey, Timothy$$b17
000143244 7001_ $$00000-0002-8802-2903$$aKhaw, Kay T$$b18
000143244 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b19$$udkfz
000143244 7001_ $$aMokoroa, Olatz$$b20
000143244 7001_ $$aNilsson, Peter M$$b21
000143244 7001_ $$aOvervad, Kim$$b22
000143244 7001_ $$aPala, Valeria$$b23
000143244 7001_ $$aPalli, Domenico$$b24
000143244 7001_ $$aPanico, Salvatore$$b25
000143244 7001_ $$aSacerdote, Carlotta$$b26
000143244 7001_ $$aSpijkerman, Annemieke M W$$b27
000143244 7001_ $$aTjonneland, Anne$$b28
000143244 7001_ $$aTumino, Rosario$$b29
000143244 7001_ $$aRodríguez-Barranco, Miguel$$b30
000143244 7001_ $$aRolandsson, Olov$$b31
000143244 7001_ $$aRiboli, Elio$$b32
000143244 7001_ $$aSharp, Stephen J$$b33
000143244 7001_ $$aLangenberg, Claudia$$b34
000143244 7001_ $$aWareham, Nicholas J$$b35
000143244 773__ $$0PERI:(DE-600)1490520-6$$a10.2337/dc18-2034$$gVol. 42, no. 4, p. 568 - 575$$n4$$p568 - 575$$tDiabetes care$$v42$$x1935-5548$$y2019
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