TY  - JOUR
AU  - Vissers, Linda E T
AU  - Sluijs, Ivonne
AU  - van der Schouw, Yvonne T
AU  - Forouhi, Nita G
AU  - Imamura, Fumiaki
AU  - Burgess, Stephen
AU  - Barricarte, Aurelio
AU  - Boeing, Heiner
AU  - Bonet, Catalina
AU  - Chirlaque, Maria-Dolores
AU  - Fagherazzi, Guy
AU  - Franks, Paul W
AU  - Freisling, Heinz
AU  - Gunter, Marc J
AU  - Quirós, J Ramón
AU  - Ibsen, Daniel B
AU  - Kaaks, Rudolf
AU  - Key, Timothy
AU  - Khaw, Kay T
AU  - Kühn, Tilman
AU  - Mokoroa, Olatz
AU  - Nilsson, Peter M
AU  - Overvad, Kim
AU  - Pala, Valeria
AU  - Palli, Domenico
AU  - Panico, Salvatore
AU  - Sacerdote, Carlotta
AU  - Spijkerman, Annemieke M W
AU  - Tjonneland, Anne
AU  - Tumino, Rosario
AU  - Rodríguez-Barranco, Miguel
AU  - Rolandsson, Olov
AU  - Riboli, Elio
AU  - Sharp, Stephen J
AU  - Langenberg, Claudia
AU  - Wareham, Nicholas J
TI  - Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study.
JO  - Diabetes care
VL  - 42
IS  - 4
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2019-00842
SP  - 568 - 575
PY  - 2019
AB  - To estimate the causal association between intake of dairy products and incident type 2 diabetes.The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, and rs4988235 (LCT-12910C>T), a single nucleotide polymorphism (SNP) for lactase persistence (LP) that enables digestion of dairy sugar, i.e., lactose, was imputed. Baseline dietary intakes were assessed with diet questionnaires. We investigated the associations between imputed SNP dosage for rs4988235 and intake of dairy products and other foods through linear regression. Mendelian randomization (MR) estimates for the milk-diabetes relationship were obtained through a two-stage least squares regression.Each additional LP allele was associated with a higher intake of milk (β 17.1 g/day, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:30728219
DO  - DOI:10.2337/dc18-2034
UR  - https://inrepo02.dkfz.de/record/143244
ER  -