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@ARTICLE{ElAyadi:143310,
      author       = {M. El-Ayadi and M. Ansari and C. D. Kühnöl and A. Bendel
                      and D. Sturm$^*$ and T. Pietsch and C. M. Kramm and A. O.
                      von Bueren},
      title        = {{O}ccurrence of high-grade glioma in {N}oonan syndrome:
                      {R}eport of two cases.},
      journal      = {Pediatric blood $\&$ cancer},
      volume       = {66},
      number       = {5},
      issn         = {1545-5017},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DKFZ-2019-00900},
      pages        = {e27625},
      year         = {2019},
      abstract     = {Noonan syndrome (NS) is an autosomal dominant disorder
                      commonly caused by PTPN11 germline mutations. Patients are
                      characterized by short stature, congenital heart defects,
                      facial dysmorphism, and increased risk of malignancies
                      including brain tumors. Commonly associated brain tumors are
                      dysembryoplastic neuroepithelial tumor and low-grade glioma.
                      We report two cases of anaplastic astrocytoma with
                      PTPN11-related NS. We conducted a systematic search of
                      medical databases looking for other reported cases of
                      high-grade glioma associated with NS and identified 24 cases
                      of brain tumors, all of which were low-grade glial or
                      glioneuronal tumors except for one case of medulloblastoma.},
      cin          = {B062},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30693642},
      doi          = {10.1002/pbc.27625},
      url          = {https://inrepo02.dkfz.de/record/143310},
}