%0 Journal Article
%A Hellwig, Malte
%A Lauffer, Marlen C
%A Bockmayr, Michael
%A Spohn, Michael
%A Merk, Daniel J
%A Harrison, Luke
%A Ahlfeld, Julia
%A Kitowski, Annabel
%A Neumann, Julia E
%A Ohli, Jasmin
%A Holdhof, Dörthe
%A Niesen, Judith
%A Schoof, Melanie
%A Kool, Marcel
%A Kraus, Cornelia
%A Zweier, Christiane
%A Holmberg, Dan
%A Schüller, Ulrich
%T TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
%J Acta neuropathologica
%V 137
%N 4
%@ 1432-0533
%C Heidelberg
%I Springer
%M DKFZ-2019-00902
%P 657 - 673
%D 2019
%X The TCF4 gene encodes for the basic helix-loop-helix transcription factor 4 (TCF4), which plays an important role in the development of the central nervous system (CNS). Haploinsufficiency of TCF4 was found to cause Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder. Recently, the screening of a large cohort of medulloblastoma (MB), a highly aggressive embryonal brain tumor, revealed almost 20
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30830316
%R 10.1007/s00401-019-01982-5
%U https://inrepo02.dkfz.de/record/143312