TY  - JOUR
AU  - Hellwig, Malte
AU  - Lauffer, Marlen C
AU  - Bockmayr, Michael
AU  - Spohn, Michael
AU  - Merk, Daniel J
AU  - Harrison, Luke
AU  - Ahlfeld, Julia
AU  - Kitowski, Annabel
AU  - Neumann, Julia E
AU  - Ohli, Jasmin
AU  - Holdhof, Dörthe
AU  - Niesen, Judith
AU  - Schoof, Melanie
AU  - Kool, Marcel
AU  - Kraus, Cornelia
AU  - Zweier, Christiane
AU  - Holmberg, Dan
AU  - Schüller, Ulrich
TI  - TCF4 (E2-2) harbors tumor suppressive functions in SHH medulloblastoma.
JO  - Acta neuropathologica
VL  - 137
IS  - 4
SN  - 1432-0533
CY  - Heidelberg
PB  - Springer
M1  - DKFZ-2019-00902
SP  - 657 - 673
PY  - 2019
AB  - The TCF4 gene encodes for the basic helix-loop-helix transcription factor 4 (TCF4), which plays an important role in the development of the central nervous system (CNS). Haploinsufficiency of TCF4 was found to cause Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder. Recently, the screening of a large cohort of medulloblastoma (MB), a highly aggressive embryonal brain tumor, revealed almost 20
LB  - PUB:(DE-HGF)16
C6  - pmid:30830316
DO  - DOI:10.1007/s00401-019-01982-5
UR  - https://inrepo02.dkfz.de/record/143312
ER  -