TY  - JOUR
AU  - Yu, Haixin
AU  - Guan, Zhong
AU  - Cuk, Katarina
AU  - Zhang, Yan
AU  - Brenner, Hermann
TI  - Circulating MicroRNA Biomarkers for Lung Cancer Detection in East Asian Populations.
JO  - Cancers
VL  - 11
IS  - 3
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-00924
SP  - 415
PY  - 2019
AB  - Lung cancer (LC) is the leading cause of cancer-related death in Eastern Asia. The prognosis of LC highly depends on tumor stages and early detection could substantially reduce LC mortality. Accumulating evidence suggested that circulating miRNAs in plasma or serum may have applications in early LC detection. We thus conducted a systematic literature review on the diagnostic value of miRNAs markers for LC in East Asian populations.PubMed and ISI Web of Knowledge were searched to retrieve relevant articles published up to 17 September 2018. Information on study design, population characteristics, investigated miRNAs and diagnostic accuracy (including sensitivity, specificity and area under the curve (AUC)) were independently extracted by two reviewers.Overall, 46 studies that evaluated a total of 88 miRNA markers for LC diagnosis in East Asian populations were identified. Sixteen of the 46 studies have incorporated individual miRNA markers as panels (with 2⁻20 markers). Three promising miRNA panels with ≥90
LB  - PUB:(DE-HGF)16
C6  - pmid:30909610
DO  - DOI:10.3390/cancers11030415
UR  - https://inrepo02.dkfz.de/record/143334
ER  -