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@ARTICLE{Yu:143334,
      author       = {H. Yu$^*$ and Z. Guan$^*$ and K. Cuk$^*$ and Y. Zhang$^*$
                      and H. Brenner$^*$},
      title        = {{C}irculating {M}icro{RNA} {B}iomarkers for {L}ung {C}ancer
                      {D}etection in {E}ast {A}sian {P}opulations.},
      journal      = {Cancers},
      volume       = {11},
      number       = {3},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2019-00924},
      pages        = {415},
      year         = {2019},
      abstract     = {Lung cancer (LC) is the leading cause of cancer-related
                      death in Eastern Asia. The prognosis of LC highly depends on
                      tumor stages and early detection could substantially reduce
                      LC mortality. Accumulating evidence suggested that
                      circulating miRNAs in plasma or serum may have applications
                      in early LC detection. We thus conducted a systematic
                      literature review on the diagnostic value of miRNAs markers
                      for LC in East Asian populations.PubMed and ISI Web of
                      Knowledge were searched to retrieve relevant articles
                      published up to 17 September 2018. Information on study
                      design, population characteristics, investigated miRNAs and
                      diagnostic accuracy (including sensitivity, specificity and
                      area under the curve (AUC)) were independently extracted by
                      two reviewers.Overall, 46 studies that evaluated a total of
                      88 miRNA markers for LC diagnosis in East Asian populations
                      were identified. Sixteen of the 46 studies have incorporated
                      individual miRNA markers as panels (with 2⁻20 markers).
                      Three promising miRNA panels with $≥90\%$ sensitivity and
                      $≥90\%$ specificity were discovered, two of which were
                      externally validated. Diagnostic performance of circulating
                      miRNAs in East Asian populations was comparable to
                      previously summarized performance in Western populations.
                      Forty-four miRNAs were reported in both populations. No
                      major differences in diagnostic performance by ethnicity of
                      the same miRNA was observed.Circulating miRNAs or miRNA
                      panels, possibly in combination with other promising
                      molecular markers including epigenetic and genetic markers,
                      may be promising candidates for noninvasive LC early
                      detection. However, large studies with samples collected
                      prospectively in true screening settings are required to
                      validate the promising markers or marker panels.},
      subtyp        = {Review Article},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30909610},
      doi          = {10.3390/cancers11030415},
      url          = {https://inrepo02.dkfz.de/record/143334},
}