000143356 001__ 143356
000143356 005__ 20240229121829.0
000143356 0247_ $$2pmid$$apmid:30896328
000143356 0247_ $$2ISSN$$a1942-325X
000143356 0247_ $$2ISSN$$a1942-3268
000143356 0247_ $$2ISSN$$a2574-8300
000143356 0247_ $$2altmetric$$aaltmetric:57667833
000143356 0247_ $$2doi$$adoi:10.1161/CIRCGEN.119.002470
000143356 037__ $$aDKFZ-2019-00944
000143356 041__ $$aeng
000143356 082__ $$a610
000143356 1001_ $$aPatel, Riyaz$$b0
000143356 245__ $$aSubsequent Event Risk in Individuals with Established Coronary Heart Disease: Design and Rationale of the GENIUS-CHD Consortium.
000143356 260__ $$aPhiladelphia, Pa.$$bLippincott, Williams & Wilkins$$c2019
000143356 3367_ $$2DRIVER$$aarticle
000143356 3367_ $$2DataCite$$aOutput Types/Journal article
000143356 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1616066747_16560
000143356 3367_ $$2BibTeX$$aARTICLE
000143356 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000143356 3367_ $$00$$2EndNote$$aJournal Article
000143356 520__ $$aThe 'GENetIcs of sUbSequent Coronary Heart Disease' (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints.GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
000143356 536__ $$0G:(DE-HGF)POF3-323$$a323 - Metabolic Dysfunction as Risk Factor (POF3-323)$$cPOF3-323$$fPOF III$$x0
000143356 588__ $$aDataset connected to PubMed,
000143356 7001_ $$aTragante, Vinicius$$b1
000143356 7001_ $$aSchmidt, Amand F$$b2
000143356 7001_ $$aMcCubrey, Raymond O$$b3
000143356 7001_ $$aHolmes, Michael V$$b4
000143356 7001_ $$aHowe, Laurence J$$b5
000143356 7001_ $$aDirek, Kenan$$b6
000143356 7001_ $$aÅkerblom, Axel$$b7
000143356 7001_ $$aLeander, Karin$$b8
000143356 7001_ $$aVirani, Salim S$$b9
000143356 7001_ $$aKaminski, Karol A$$b10
000143356 7001_ $$aMuehlschlegel, Jochen D$$b11
000143356 7001_ $$aAllayee, Hooman$$b12
000143356 7001_ $$aAlmgren, Peter$$b13
000143356 7001_ $$aAlver, Maris$$b14
000143356 7001_ $$aBaranova, Ekaterina V$$b15
000143356 7001_ $$aBehlouli, Hassan$$b16
000143356 7001_ $$aBoeckx, Bram$$b17
000143356 7001_ $$aBraund, Peter S$$b18
000143356 7001_ $$aBreitling, Lutz P$$b19
000143356 7001_ $$aDelgado, Graciela$$b20
000143356 7001_ $$aDuarte, Nubia E$$b21
000143356 7001_ $$aDubé, Marie-Pierre$$b22
000143356 7001_ $$aDufresne, Line$$b23
000143356 7001_ $$aEriksson, Niclas$$b24
000143356 7001_ $$aFoco, Luisa$$b25
000143356 7001_ $$aScholz, Markus$$b26
000143356 7001_ $$aGijsberts, Crystel M$$b27
000143356 7001_ $$aGlinge, Charlotte$$b28
000143356 7001_ $$aGong, Yan$$b29
000143356 7001_ $$aHartiala, Jaana$$b30
000143356 7001_ $$aHeydarpour, Mahyar$$b31
000143356 7001_ $$aHubacek, Jaroslav A$$b32
000143356 7001_ $$aKleber, Marcus$$b33
000143356 7001_ $$aKofink, Daniel$$b34
000143356 7001_ $$aKotti, Salma$$b35
000143356 7001_ $$aKuukasjärvi, Pekka$$b36
000143356 7001_ $$aLee, Vei-Vei$$b37
000143356 7001_ $$aLeiherer, Andreas$$b38
000143356 7001_ $$aLenzini, Petra A$$b39
000143356 7001_ $$aLevin, Daniel$$b40
000143356 7001_ $$aLyytikäinen, Leo-Pekka$$b41
000143356 7001_ $$aMartinelli, Nicola$$b42
000143356 7001_ $$0P:(DE-He78)1b59582b6c05ac4e57aa8b90dd9667f9$$aMons, Ute$$b43$$udkfz
000143356 7001_ $$aNelson, Christopher P$$b44
000143356 7001_ $$aNikus, Kjell$$b45
000143356 7001_ $$aPilbrow, Anna P$$b46
000143356 7001_ $$aPloski, Rafal$$b47
000143356 7001_ $$aSun, Yan V$$b48
000143356 7001_ $$aTanck, Michael W T$$b49
000143356 7001_ $$aTang, W H Wilson$$b50
000143356 7001_ $$aTrompet, Stella$$b51
000143356 7001_ $$avan der Laan, Sander W$$b52
000143356 7001_ $$aVan Setten, Jessica$$b53
000143356 7001_ $$aVilmundarson, Ragnar O$$b54
000143356 7001_ $$aViviani Anselmi, Chiara$$b55
000143356 7001_ $$aVlachopoulou, Efthymia$$b56
000143356 7001_ $$aAl Ali, Lawien$$b57
000143356 7001_ $$aBoerwinkle, Eric$$b58
000143356 7001_ $$aBriguori, Carlo$$b59
000143356 7001_ $$aCarlquist, John F$$b60
000143356 7001_ $$aCarruthers, Kathryn F$$b61
000143356 7001_ $$aCasu, Gavino$$b62
000143356 7001_ $$aDeanfield, John$$b63
000143356 7001_ $$aDeloukas, Panos$$b64
000143356 7001_ $$aDudbridge, Frank$$b65
000143356 7001_ $$aEngström, Thomas$$b66
000143356 7001_ $$aFitzpatrick, Natalie$$b67
000143356 7001_ $$aFox, Kim$$b68
000143356 7001_ $$aGigante, Bruna$$b69
000143356 7001_ $$aJames, Stefan$$b70
000143356 7001_ $$aLokki, Marja-Liisa$$b71
000143356 7001_ $$aLotufo, Paulo A$$b72
000143356 7001_ $$aMarziliano, Nicola$$b73
000143356 7001_ $$aMordi, Ify R$$b74
000143356 7001_ $$aMuhlestein, Joseph B$$b75
000143356 7001_ $$aNewton-Cheh, Christopher$$b76
000143356 7001_ $$aPitha, Jan$$b77
000143356 7001_ $$aSaely, Christoph H$$b78
000143356 7001_ $$aSamman-Tahhan, Ayman$$b79
000143356 7001_ $$aSandesara, Pratik B$$b80
000143356 7001_ $$aTeren, Andrej$$b81
000143356 7001_ $$aTimmis, Adam$$b82
000143356 7001_ $$aVan de Werf, Frans$$b83
000143356 7001_ $$aWauters, Els$$b84
000143356 7001_ $$aWilde, Arthur A M$$b85
000143356 7001_ $$aFord, Ian$$b86
000143356 7001_ $$aStott, David J$$b87
000143356 7001_ $$aAlgra, Ale$$b88
000143356 7001_ $$aAndreassi, Maria G$$b89
000143356 7001_ $$aArdissino, Diego$$b90
000143356 7001_ $$aArsenault, Benoit J$$b91
000143356 7001_ $$aBallantyne, Christie M$$b92
000143356 7001_ $$aBergmeijer, Thomas O$$b93
000143356 7001_ $$aBezzina, Connie R$$b94
000143356 7001_ $$aBody, Simon C$$b95
000143356 7001_ $$aBoersma, Eric H$$b96
000143356 7001_ $$aBogaty, Peter$$b97
000143356 7001_ $$aBots, Michiel$$b98
000143356 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b99$$udkfz
000143356 7001_ $$aBrugts, Jasper J$$b100
000143356 7001_ $$aBurkhardt, Ralph$$b101
000143356 7001_ $$aCarpeggiani, Clara$$b102
000143356 7001_ $$aCondorelli, Gianluigi$$b103
000143356 7001_ $$aCooper-DeHoff, Rhonda M$$b104
000143356 7001_ $$aCresci, Sharon$$b105
000143356 7001_ $$aDanchin, Nicolas$$b106
000143356 7001_ $$ade Faire, Ulf$$b107
000143356 7001_ $$aDoughty, Robert N$$b108
000143356 7001_ $$aDrexel, Heinz$$b109
000143356 7001_ $$aEngert, James C$$b110
000143356 7001_ $$aFox, Keith A A$$b111
000143356 7001_ $$aGirelli, Domenico$$b112
000143356 7001_ $$aGrobbee, Diederick E$$b113
000143356 7001_ $$aHagström, Emil$$b114
000143356 7001_ $$aHazen, Stanley L$$b115
000143356 7001_ $$aHeld, Claes$$b116
000143356 7001_ $$aHemingway, Harry$$b117
000143356 7001_ $$aHoefer, Imo E$$b118
000143356 7001_ $$aHovingh, G Kees$$b119
000143356 7001_ $$aJabbari, Reza$$b120
000143356 7001_ $$aJohnson, Julie A$$b121
000143356 7001_ $$aJukema, J Wouter$$b122
000143356 7001_ $$aKaczor, Marcin P$$b123
000143356 7001_ $$aKähönen, Mika$$b124
000143356 7001_ $$aKettner, Jiri$$b125
000143356 7001_ $$aKiliszek, Marek$$b126
000143356 7001_ $$aKlungel, Olaf H$$b127
000143356 7001_ $$aLagerqvist, Bo$$b128
000143356 7001_ $$aLambrechts, Diether$$b129
000143356 7001_ $$aLaurikka, Jari O$$b130
000143356 7001_ $$aLehtimäki, Terho$$b131
000143356 7001_ $$aLindholm, Daniel$$b132
000143356 7001_ $$aMahmoodi, B. K.$$b133
000143356 7001_ $$aMaitland-van der Zee, Anke H$$b134
000143356 7001_ $$aMcPherson, Ruth$$b135
000143356 7001_ $$aMelander, Olle$$b136
000143356 7001_ $$aMetspalu, Andres$$b137
000143356 7001_ $$aNiemcunowicz-Janica, Anna$$b138
000143356 7001_ $$aOlivieri, Oliviero$$b139
000143356 7001_ $$aOpolski, Grzegorz$$b140
000143356 7001_ $$aPalmer, Colin N$$b141
000143356 7001_ $$aPasterkamp, Gerard$$b142
000143356 7001_ $$aPepine, Carl J$$b143
000143356 7001_ $$aPereira, Alexandre C$$b144
000143356 7001_ $$aPilote, Louise$$b145
000143356 7001_ $$aQuyyumi, Arshed A$$b146
000143356 7001_ $$aRichards, A Mark$$b147
000143356 7001_ $$aSanak, Marek$$b148
000143356 7001_ $$aSiegbahn, Agneta$$b149
000143356 7001_ $$aSimon, Tabassome$$b150
000143356 7001_ $$aSinisalo, Juha$$b151
000143356 7001_ $$aSmith, J Gustav$$b152
000143356 7001_ $$aSpertus, John A$$b153
000143356 7001_ $$aStender, Steen$$b154
000143356 7001_ $$aStewart, Alexandre F R$$b155
000143356 7001_ $$aSzczeklik, Wojciech$$b156
000143356 7001_ $$aSzpakowicz, Anna$$b157
000143356 7001_ $$aTardif, Jean-Claude$$b158
000143356 7001_ $$aTen Berg, Jurriën M$$b159
000143356 7001_ $$aTfelt-Hansen, Jacob$$b160
000143356 7001_ $$aThanassoulis, George$$b161
000143356 7001_ $$aThiery, Joachim$$b162
000143356 7001_ $$aTorp-Pedersen, Christian$$b163
000143356 7001_ $$avan der Graaf, Yolanda$$b164
000143356 7001_ $$aVisseren, Frank L J$$b165
000143356 7001_ $$aWaltenberger, Johannes$$b166
000143356 7001_ $$aWeeke, Peter E$$b167
000143356 7001_ $$aVan der Harst, Pim$$b168
000143356 7001_ $$aLang, Chim C$$b169
000143356 7001_ $$aSattar, Naveed$$b170
000143356 7001_ $$aCameron, Vicky A$$b171
000143356 7001_ $$aAnderson, Jeffrey L$$b172
000143356 7001_ $$aBrophy, James M$$b173
000143356 7001_ $$aParé, Guillaume$$b174
000143356 7001_ $$aHorne, Benjamin D$$b175
000143356 7001_ $$aMärz, Winfried$$b176
000143356 7001_ $$aWallentin, Lars$$b177
000143356 7001_ $$aSamani, Nilesh J$$b178
000143356 7001_ $$aHingorani, Aroon D$$b179
000143356 7001_ $$aAsselbergs, Folkert W$$b180
000143356 773__ $$0PERI:(DE-600)2457085-0$$a10.1161/CIRCGEN.119.002470$$n4$$pe002470$$tCirculation Genomic and precision medicine [...]$$v12$$x2574-8300$$y2019
000143356 909CO $$ooai:inrepo02.dkfz.de:143356$$pVDB
000143356 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)1b59582b6c05ac4e57aa8b90dd9667f9$$aDeutsches Krebsforschungszentrum$$b43$$kDKFZ
000143356 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b99$$kDKFZ
000143356 9131_ $$0G:(DE-HGF)POF3-323$$1G:(DE-HGF)POF3-320$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lHerz-Kreislauf-Stoffwechselerkrankungen$$vMetabolic Dysfunction as Risk Factor$$x0
000143356 9132_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000143356 9141_ $$y2019
000143356 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCIRC-CARDIOVASC GENE : 2017
000143356 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000143356 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000143356 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000143356 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000143356 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000143356 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000143356 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000143356 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000143356 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCIRC-CARDIOVASC GENE : 2017
000143356 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000143356 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000143356 980__ $$ajournal
000143356 980__ $$aVDB
000143356 980__ $$aI:(DE-He78)C070-20160331
000143356 980__ $$aI:(DE-He78)C120-20160331
000143356 980__ $$aUNRESTRICTED