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@ARTICLE{Patel:143356,
      author       = {R. Patel and V. Tragante and A. F. Schmidt and R. O.
                      McCubrey and M. V. Holmes and L. J. Howe and K. Direk and A.
                      Åkerblom and K. Leander and S. S. Virani and K. A. Kaminski
                      and J. D. Muehlschlegel and H. Allayee and P. Almgren and M.
                      Alver and E. V. Baranova and H. Behlouli and B. Boeckx and
                      P. S. Braund and L. P. Breitling and G. Delgado and N. E.
                      Duarte and M.-P. Dubé and L. Dufresne and N. Eriksson and
                      L. Foco and M. Scholz and C. M. Gijsberts and C. Glinge and
                      Y. Gong and J. Hartiala and M. Heydarpour and J. A. Hubacek
                      and M. Kleber and D. Kofink and S. Kotti and P. Kuukasjärvi
                      and V.-V. Lee and A. Leiherer and P. A. Lenzini and D. Levin
                      and L.-P. Lyytikäinen and N. Martinelli and U. Mons$^*$ and
                      C. P. Nelson and K. Nikus and A. P. Pilbrow and R. Ploski
                      and Y. V. Sun and M. W. T. Tanck and W. H. W. Tang and S.
                      Trompet and S. W. van der Laan and J. Van Setten and R. O.
                      Vilmundarson and C. Viviani Anselmi and E. Vlachopoulou and
                      L. Al Ali and E. Boerwinkle and C. Briguori and J. F.
                      Carlquist and K. F. Carruthers and G. Casu and J. Deanfield
                      and P. Deloukas and F. Dudbridge and T. Engström and N.
                      Fitzpatrick and K. Fox and B. Gigante and S. James and M.-L.
                      Lokki and P. A. Lotufo and N. Marziliano and I. R. Mordi and
                      J. B. Muhlestein and C. Newton-Cheh and J. Pitha and C. H.
                      Saely and A. Samman-Tahhan and P. B. Sandesara and A. Teren
                      and A. Timmis and F. Van de Werf and E. Wauters and A. A. M.
                      Wilde and I. Ford and D. J. Stott and A. Algra and M. G.
                      Andreassi and D. Ardissino and B. J. Arsenault and C. M.
                      Ballantyne and T. O. Bergmeijer and C. R. Bezzina and S. C.
                      Body and E. H. Boersma and P. Bogaty and M. Bots and H.
                      Brenner$^*$ and J. J. Brugts and R. Burkhardt and C.
                      Carpeggiani and G. Condorelli and R. M. Cooper-DeHoff and S.
                      Cresci and N. Danchin and U. de Faire and R. N. Doughty and
                      H. Drexel and J. C. Engert and K. A. A. Fox and D. Girelli
                      and D. E. Grobbee and E. Hagström and S. L. Hazen and C.
                      Held and H. Hemingway and I. E. Hoefer and G. K. Hovingh and
                      R. Jabbari and J. A. Johnson and J. W. Jukema and M. P.
                      Kaczor and M. Kähönen and J. Kettner and M. Kiliszek and
                      O. H. Klungel and B. Lagerqvist and D. Lambrechts and J. O.
                      Laurikka and T. Lehtimäki and D. Lindholm and B. K.
                      Mahmoodi and A. H. Maitland-van der Zee and R. McPherson and
                      O. Melander and A. Metspalu and A. Niemcunowicz-Janica and
                      O. Olivieri and G. Opolski and C. N. Palmer and G.
                      Pasterkamp and C. J. Pepine and A. C. Pereira and L. Pilote
                      and A. A. Quyyumi and A. M. Richards and M. Sanak and A.
                      Siegbahn and T. Simon and J. Sinisalo and J. G. Smith and J.
                      A. Spertus and S. Stender and A. F. R. Stewart and W.
                      Szczeklik and A. Szpakowicz and J.-C. Tardif and J. M. Ten
                      Berg and J. Tfelt-Hansen and G. Thanassoulis and J. Thiery
                      and C. Torp-Pedersen and Y. van der Graaf and F. L. J.
                      Visseren and J. Waltenberger and P. E. Weeke and P. Van der
                      Harst and C. C. Lang and N. Sattar and V. A. Cameron and J.
                      L. Anderson and J. M. Brophy and G. Paré and B. D. Horne
                      and W. März and L. Wallentin and N. J. Samani and A. D.
                      Hingorani and F. W. Asselbergs},
      title        = {{S}ubsequent {E}vent {R}isk in {I}ndividuals with
                      {E}stablished {C}oronary {H}eart {D}isease: {D}esign and
                      {R}ationale of the {GENIUS}-{CHD} {C}onsortium.},
      journal      = {Circulation Genomic and precision medicine [...]},
      volume       = {12},
      number       = {4},
      issn         = {2574-8300},
      address      = {Philadelphia, Pa.},
      publisher    = {Lippincott, Williams $\&$ Wilkins},
      reportid     = {DKFZ-2019-00944},
      pages        = {e002470},
      year         = {2019},
      abstract     = {The 'GENetIcs of sUbSequent Coronary Heart Disease'
                      (GENIUS-CHD) consortium was established to facilitate
                      discovery and validation of genetic variants and biomarkers
                      for risk of subsequent CHD events, in individuals with
                      established CHD.The consortium currently includes 57 studies
                      from 18 countries, recruiting 185,614 participants with
                      either acute coronary syndrome, stable CHD or a mixture of
                      both at baseline. All studies collected biological samples
                      and followed-up study participants prospectively for
                      subsequent events.Enrollment into the individual studies
                      took place between 1985 to present day with duration of
                      follow up ranging from 9 months to 15 years. Within each
                      study, participants with CHD are predominantly of
                      self-reported European descent $(38\%-100\%),$ mostly male
                      $(44\%-91\%)$ with mean ages at recruitment ranging from 40
                      to 75 years. Initial feasibility analyses, using a federated
                      analysis approach, yielded expected associations between age
                      (HR 1.15 $95\%$ CI 1.14-1.16) per 5-year increase, male sex
                      (HR 1.17, $95\%$ CI 1.13-1.21) and smoking (HR 1.43, $95\%$
                      CI 1.35-1.51) with risk of subsequent CHD death or
                      myocardial infarction, and differing associations with other
                      individual and composite cardiovascular endpoints.GENIUS-CHD
                      is a global collaboration seeking to elucidate genetic and
                      non-genetic determinants of subsequent event risk in
                      individuals with established CHD, in order to improve
                      residual risk prediction and identify novel drug targets for
                      secondary prevention. Initial analyses demonstrate the
                      feasibility and reliability of a federated analysis
                      approach. The consortium now plans to initiate and test
                      novel hypotheses as well as supporting replication and
                      validation analyses for other investigators.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30896328},
      doi          = {10.1161/CIRCGEN.119.002470},
      url          = {https://inrepo02.dkfz.de/record/143356},
}