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@ARTICLE{Fortner:143359,
      author       = {R. Fortner$^*$ and K. L. Terry and N. Bender$^*$ and N.
                      Brenner$^*$ and K. Hufnagel$^*$ and J. Butt$^*$ and T.
                      Waterboer$^*$ and S. S. Tworoger},
      title        = {{S}exually transmitted infections and risk of epithelial
                      ovarian cancer: results from the {N}urses' {H}ealth
                      {S}tudies.},
      journal      = {British journal of cancer},
      volume       = {120},
      number       = {8},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2019-00947},
      pages        = {855-860},
      year         = {2019},
      note         = {;120(8):855-860, mm},
      abstract     = {Sexually transmitted infections (STIs) are associated with
                      pelvic inflammatory disease and tubal pathologies. Given the
                      tubal origin of a proportion of ovarian cancers, STIs may be
                      relevant in their aetiology.Antibodies indicating past
                      infection with Chlamydia trachomatis, Mycoplasma
                      genitalium, herpes simplex virus type 2, and against human
                      papillomavirus oncogenes (L1 and E6+E7 oncoproteins of types
                      16, 18, 45) were measured in prediagnosis plasma samples in
                      a nested case-control study in the Nurses' Health Studies
                      (n = 337 cases 1:1 matched to controls). Logistic
                      regression was used to estimate multivariable-adjusted
                      relative risks (RRs) and $95\%$ confidence intervals [CIs]
                      comparing women seropositive vs. seronegative among all
                      cases (invasive and borderline), invasive (n = 257), and
                      invasive serous ovarian cancers; n = 170), and
                      borderline ovarian tumours (n = 80).C. trachomatis
                      seropositivity was associated with higher risk of ovarian
                      cancer overall (RR = 2.07 [1.25-3.43]); results were
                      similar for invasive, invasive serous, and borderline
                      tumours. We observed no associations for the other STIs.
                      Relative to women seronegative to all infections, strongest
                      associations were observed for seropositivity to C.
                      trachomatis plus another STI (2.74 [1.20-6.27]; C.
                      trachomatis alone, 1.88 [1.03-3.42]; all cases); however,
                      the RRs were not significantly different.C. trachomatis
                      infection may increase ovarian cancer risk; additional
                      studies are required.},
      cin          = {C020 / F020 / F022},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)F020-20160331 /
                      I:(DE-He78)F022-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30894687},
      doi          = {10.1038/s41416-019-0422-9},
      url          = {https://inrepo02.dkfz.de/record/143359},
}