TY  - JOUR
AU  - Held, Thomas
AU  - Akbaba, Sati
AU  - Lang, Kristin
AU  - Harrabi, Semi
AU  - Bernhardt, Denise
AU  - Freudlsperger, Christian
AU  - Kargus, Steffen
AU  - Plinkert, Peter
AU  - Rieken, Stefan
AU  - Herfarth, Klaus
AU  - Debus, Jürgen
AU  - Adeberg, Sebastian
TI  - Clinical Management of Blood⁻Brain Barrier Disruptions after Active Raster-Scanned Carbon Ion Re-Radiotherapy in Patients with Recurrent Head-and-Neck Cancer.
JO  - Cancers
VL  - 11
IS  - 3
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-00948
SP  - 383 
PY  - 2019
AB  - Purpose: The aim of the current evaluation was to assess central nervous system necrosis (CNSN) after re-irradiation with carbon ions (CR) in two-hundred seventeen (n = 217) patients with recurrent head-and-neck cancer (HNC). Methods: Thirty-six (n = 36) patients with CNSN were assessed retrospectively regarding clinical symptoms and radiographic response. Results: CNSN were classified according to clinical management in line with the Common Terminology Criteria for Adverse Events (CTCAE) v5.0. At a median follow-up of 25.3 months (range 3.3⁻79.9 months), the median time interval until occurrence of grade I, II, and III CNSN was 9.2 months (range 2.8⁻75.0 months), 10.2 months (range 2.3⁻60.5 months), and 16.6 months (range 8.7⁻32.5 months), respectively. In one patient with an adenocarcinoma infiltrating the frontal lobe, an extensive CNSN grade IV was suspected but the patient declined surgical intervention. Radiographic response after treatment of CNSN grade I, II, and III, defined as ≥25
LB  - PUB:(DE-HGF)16
C6  - pmid:30893824
DO  - DOI:10.3390/cancers11030383
UR  - https://inrepo02.dkfz.de/record/143360
ER  -