%0 Journal Article
%A Schübel, Ruth
%A Sookthai, Disorn
%A Greimel, Judith
%A Johnson, Theron S
%A Grafetstätter, Mirja E
%A Kirsten, Romy
%A Kratz, Mario
%A Ulrich, Cornelia M
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss.
%J Nutrients
%V 11
%N 3
%@ 2072-6643
%C Basel
%I MDPI
%M DKFZ-2019-00960
%P 639 
%D 2019
%X Smaller cross-sectional studies and bariatric surgery trials suggest that weight loss may change the expression of genes in adipose tissue that have been implicated in the development of metabolic diseases, but well-powered intervention trials are lacking. In post hoc analyses of data from a 12-week dietary intervention trial initially designed to compare metabolic effects of intermittent vs. continuous calorie restriction, we analyzed the effects of overall weight loss on the subcutaneous adipose tissue (SAT) transcriptome. Changes in the transcriptome were measured by microarray using SAT samples of 138 overweight or obese individuals (age range: 35⁻65 years, BMI range: 25⁻40, non-smokers, non-diabetics). Participants were grouped post hoc according to the degree of their weight loss by quartiles (average weight loss in quartiles 1 to 4: 0
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30884788
%R 10.3390/nu11030639
%U https://inrepo02.dkfz.de/record/143372