TY  - JOUR
AU  - Schübel, Ruth
AU  - Sookthai, Disorn
AU  - Greimel, Judith
AU  - Johnson, Theron S
AU  - Grafetstätter, Mirja E
AU  - Kirsten, Romy
AU  - Kratz, Mario
AU  - Ulrich, Cornelia M
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Key Genes of Lipid Metabolism and WNT-Signaling Are Downregulated in Subcutaneous Adipose Tissue with Moderate Weight Loss.
JO  - Nutrients
VL  - 11
IS  - 3
SN  - 2072-6643
CY  - Basel
PB  - MDPI
M1  - DKFZ-2019-00960
SP  - 639 
PY  - 2019
AB  - Smaller cross-sectional studies and bariatric surgery trials suggest that weight loss may change the expression of genes in adipose tissue that have been implicated in the development of metabolic diseases, but well-powered intervention trials are lacking. In post hoc analyses of data from a 12-week dietary intervention trial initially designed to compare metabolic effects of intermittent vs. continuous calorie restriction, we analyzed the effects of overall weight loss on the subcutaneous adipose tissue (SAT) transcriptome. Changes in the transcriptome were measured by microarray using SAT samples of 138 overweight or obese individuals (age range: 35⁻65 years, BMI range: 25⁻40, non-smokers, non-diabetics). Participants were grouped post hoc according to the degree of their weight loss by quartiles (average weight loss in quartiles 1 to 4: 0
LB  - PUB:(DE-HGF)16
C6  - pmid:30884788
DO  - DOI:10.3390/nu11030639
UR  - https://inrepo02.dkfz.de/record/143372
ER  -