% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Srinivas:143386,
      author       = {N. Srinivas$^*$ and S. Rachakonda$^*$ and T. Hielscher$^*$
                      and S. Calderazzo and P. Rudnai and E. Gurzau and K. Koppova
                      and T. Fletcher and R. Kumar$^*$},
      title        = {{T}elomere length, arsenic exposure and risk of basal cell
                      carcinoma of skin.},
      journal      = {Carcinogenesis},
      volume       = {40},
      number       = {6},
      issn         = {1460-2180},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2019-00974},
      pages        = {715-723},
      year         = {2019},
      abstract     = {Telomere length per se a heritable trait has been reported
                      to be associated with different diseases including cancers.
                      In this study based on arsenic exposed 528 cases with basal
                      cell carcinoma of skin (BCC) and 533 healthy controls we
                      investigated effect of telomere length, measured by
                      real-time PCR, on the disease risk. We observed a
                      statistically significant association between decreased
                      telomere length and increased BCC risk (OR = 5.92, $95\%$ CI
                      = 3.92-9.01, P<0.0001). Due to confounder effect of arsenic
                      exposure, in a two-sample Mendelian randomization (MR),
                      telomere-length associated single nucleotide polymorphisms
                      as instrument variables violated valid assumptions; however,
                      one-sample MR adjusted for arsenic exposure indicated an
                      increased risk of BCC with short telomeres. The interaction
                      between arsenic exposure and telomere length on BCC risk was
                      statistically significant (P = 0.02). Within each tertile
                      based on arsenic exposure, the individuals with shorter
                      telomeres were at an increased risk of BCC, with highest
                      risk being in the highest exposed group (OR = 16.13, $95\%$
                      CI = 6.71-40.00, P<0.0001); followed by those in medium
                      exposure group and low exposure group. The combined effect
                      of highest arsenic exposure and shortest telomeres on BCC
                      risk (OR = 10.56, $95\%$ CI = 5.14-21.70) showed a
                      statistically significant departure from additivity
                      (interaction constant ratio 6.56, P = 0.03). Our results
                      show that in the presence of arsenic exposure, decreased
                      telomere length predisposes individuals to increased risk of
                      BCC, with the effect being synergistic in individuals with
                      highest arsenic exposure and shortest telomeres.},
      cin          = {C050 / C060 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C050-20160331 / I:(DE-He78)C060-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30874287},
      doi          = {10.1093/carcin/bgz059},
      url          = {https://inrepo02.dkfz.de/record/143386},
}