TY  - JOUR
AU  - Lu, Yingchang
AU  - Kweon, Sun-Seog
AU  - Tanikawa, Chizu
AU  - Jia, Wei-Hua
AU  - Xiang, Yong-Bing
AU  - Cai, Qiuyin
AU  - Zeng, Chenjie
AU  - Schmit, Stephanie L
AU  - Shin, Aesun
AU  - Matsuo, Keitaro
AU  - Jee, Sun Ha
AU  - Kim, Dong-Hyun
AU  - Kim, Jeongseon
AU  - Wen, Wanqing
AU  - Shi, Jiajun
AU  - Guo, Xingyi
AU  - Li, Bingshan
AU  - Wang, Nan
AU  - Zhang, Ben
AU  - Li, Xinxiang
AU  - Shin, Min-Ho
AU  - Li, Hong-Lan
AU  - Ren, Zefang
AU  - Oh, Jae Hwan
AU  - Oze, Isao
AU  - Ahn, Yoon-Ok
AU  - Jung, Keum Ji
AU  - Conti, David V
AU  - Schumacher, Fredrick R
AU  - Rennert, Gad
AU  - Jenkins, Mark A
AU  - Campbell, Peter T
AU  - Hoffmeister, Michael
AU  - Casey, Graham
AU  - Gruber, Stephen B
AU  - Gao, Jing
AU  - Gao, Yu-Tang
AU  - Pan, Zhi-Zhong
AU  - Kamatani, Yoichiro
AU  - Zeng, Yi-Xin
AU  - Shu, Xiao-Ou
AU  - Long, Jirong
AU  - Matsuda, Koichi
AU  - Zheng, Wei
TI  - Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
JO  - Gastroenterology
VL  - 156
IS  - 5
SN  - 0016-5085
CY  - Philadelphia, Pa. [u.a.]
PB  - Saunders
M1  - DKFZ-2019-01006
SP  - 1455 - 1466
PY  - 2019
AB  - Genome-wide association studies (GWASs) have associated approximately 50 loci with risk of colorectal cancer (CRC)-nearly one third of these loci were initially associated with CRC in studies conducted in East Asian populations. We conducted a GWAS of East Asians to identify CRC risk loci and evaluate the generalizability of findings from GWASs of European populations to Asian populations.We analyzed genetic data from 22,775 patients with CRC (cases) and 47,731 individuals without cancer (controls) from 14 studies in the Asia Colorectal Cancer Consortium. First, we performed a meta-analysis of 7 GWASs (10,625 cases and 34,595 controls) and identified 46,554 promising risk variants for replication by adding them to the Multi-Ethnic Global Array (MEGA) for genotype analysis in 6445 cases and 7175 controls. These data were analyzed, along with data from an additional 5705 cases and 5961 controls genotyped using the OncoArray. We also obtained data from 57,976 cases and 67,242 controls of European descent. Variants at identified risk loci were functionally annotated and evaluated in correlation with gene expression levels.A meta-analyses of all samples from people of Asian descent identified 13 loci and 1 new variant at a known locus (10q24.2) associated with risk of CRC at the genome-wide significance level of P < 5 × 10-8. We did not perform experiments to replicate these associations in additional individuals of Asian ancestry. However, the lead risk variant in 6 of these loci was also significantly associated with risk of CRC in European descendants. A strong association (44
LB  - PUB:(DE-HGF)16
C6  - pmid:30529582
C2  - pmc:PMC6441622
DO  - DOI:10.1053/j.gastro.2018.11.066
UR  - https://inrepo02.dkfz.de/record/143418
ER  -