% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Wirbel:143429,
      author       = {J. Wirbel and P. T. Pyl and E. Kartal and K. Zych and A.
                      Kashani and A. Milanese and J. S. Fleck and A. Y. Voigt and
                      A. Palleja and R. Ponnudurai and S. Sunagawa and L. P.
                      Coelho and P. Schrotz-King$^*$ and E. Vogtmann and N.
                      Habermann and E. Niméus and A. M. Thomas and P. Manghi and
                      S. Gandini and D. Serrano and S. Mizutani and H. Shiroma and
                      S. Shiba and T. Shibata and S. Yachida and T. Yamada and L.
                      Waldron and A. Naccarati and N. Segata and R. Sinha and C.
                      M. Ulrich and H. Brenner$^*$ and M. Arumugam and P. Bork and
                      G. Zeller},
      title        = {{M}eta-analysis of fecal metagenomes reveals global
                      microbial signatures that are specific for colorectal
                      cancer.},
      journal      = {Nature medicine},
      volume       = {25},
      number       = {4},
      issn         = {1546-170X},
      address      = {New York, NY},
      publisher    = {Nature America Inc.},
      reportid     = {DKFZ-2019-01017},
      pages        = {679 - 689},
      year         = {2019},
      abstract     = {Association studies have linked microbiome alterations with
                      many human diseases. However, they have not always reported
                      consistent results, thereby necessitating cross-study
                      comparisons. Here, a meta-analysis of eight geographically
                      and technically diverse fecal shotgun metagenomic studies of
                      colorectal cancer (CRC, n = 768), which was controlled
                      for several confounders, identified a core set of 29 species
                      significantly enriched in CRC metagenomes (false discovery
                      rate (FDR) < 1 × 10-5). CRC signatures derived from
                      single studies maintained their accuracy in other studies.
                      By training on multiple studies, we improved detection
                      accuracy and disease specificity for CRC. Functional
                      analysis of CRC metagenomes revealed enriched protein and
                      mucin catabolism genes and depleted carbohydrate degradation
                      genes. Moreover, we inferred elevated production of
                      secondary bile acids from CRC metagenomes, suggesting a
                      metabolic link between cancer-associated gut microbes and a
                      fat- and meat-rich diet. Through extensive validations, this
                      meta-analysis firmly establishes globally generalizable,
                      predictive taxonomic and functional microbiome CRC
                      signatures as a basis for future diagnostics.},
      cin          = {C120 / C070 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30936547},
      doi          = {10.1038/s41591-019-0406-6},
      url          = {https://inrepo02.dkfz.de/record/143429},
}