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000143430 0247_ $$2doi$$a10.1101/gr.242453.118
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000143430 0247_ $$2ISSN$$a1088-9051
000143430 0247_ $$2ISSN$$a1549-5469
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000143430 037__ $$aDKFZ-2019-01018
000143430 041__ $$aeng
000143430 082__ $$a540
000143430 1001_ $$aZhivagui, Maria$$b0
000143430 245__ $$aExperimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
000143430 260__ $$aCold Spring Harbor, NY$$bLaboratory Press$$c2019
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000143430 520__ $$aHumans are frequently exposed to acrylamide, a probable human carcinogen found in commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence has shown that acrylamide causes cancer in rodents, yet epidemiological studies conducted to date are limited and, thus far, have yielded inconclusive data on association of human cancers with acrylamide exposure. In this study, we experimentally identify a novel and unique mutational signature imprinted by acrylamide through the effects of its reactive metabolite glycidamide. We next show that the glycidamide mutational signature is found in a full one-third of approximately 1600 tumor genomes corresponding to 19 human tumor types from 14 organs. The highest enrichment of the glycidamide signature was observed in the cancers of the lung (88% of the interrogated tumors), liver (73%), kidney (>70%), bile duct (57%), cervix (50%), and, to a lesser extent, additional cancer types. Overall, our study reveals an unexpectedly extensive contribution of acrylamide-associated mutagenesis to human cancers.
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000143430 7001_ $$aNg, Alvin W T$$b1
000143430 7001_ $$aArdin, Maude$$b2
000143430 7001_ $$aChurchwell, Mona I$$b3
000143430 7001_ $$aPandey, Manuraj$$b4
000143430 7001_ $$aRenard, Claire$$b5
000143430 7001_ $$aVillar, Stephanie$$b6
000143430 7001_ $$aCahais, Vincent$$b7
000143430 7001_ $$aRobitaille, Alexis$$b8
000143430 7001_ $$aBouaoun, Liacine$$b9
000143430 7001_ $$aHeguy, Adriana$$b10
000143430 7001_ $$aGuyton, Kathryn Z$$b11
000143430 7001_ $$aStampfer, Martha R$$b12
000143430 7001_ $$aMcKay, James$$b13
000143430 7001_ $$0P:(DE-He78)f3bec70c95e9e3dce0f39d54b3843118$$aHollstein, Monica$$b14$$udkfz
000143430 7001_ $$aOlivier, Magali$$b15
000143430 7001_ $$aRozen, Steven G$$b16
000143430 7001_ $$aBeland, Frederick A$$b17
000143430 7001_ $$aKorenjak, Michael$$b18
000143430 7001_ $$aZavadil, Jiri$$b19
000143430 773__ $$0PERI:(DE-600)1483456-x$$a10.1101/gr.242453.118$$gVol. 29, no. 4, p. 521 - 531$$n4$$p521 - 531$$tGenome research$$v29$$x1549-5469$$y2019
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000143430 9141_ $$y2019
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