TY  - JOUR
AU  - Zhivagui, Maria
AU  - Ng, Alvin W T
AU  - Ardin, Maude
AU  - Churchwell, Mona I
AU  - Pandey, Manuraj
AU  - Renard, Claire
AU  - Villar, Stephanie
AU  - Cahais, Vincent
AU  - Robitaille, Alexis
AU  - Bouaoun, Liacine
AU  - Heguy, Adriana
AU  - Guyton, Kathryn Z
AU  - Stampfer, Martha R
AU  - McKay, James
AU  - Hollstein, Monica
AU  - Olivier, Magali
AU  - Rozen, Steven G
AU  - Beland, Frederick A
AU  - Korenjak, Michael
AU  - Zavadil, Jiri
TI  - Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
JO  - Genome research
VL  - 29
IS  - 4
SN  - 1549-5469
CY  - Cold Spring Harbor, NY
PB  - Laboratory Press
M1  - DKFZ-2019-01018
SP  - 521 - 531
PY  - 2019
AB  - Humans are frequently exposed to acrylamide, a probable human carcinogen found in commonplace sources such as most heated starchy foods or tobacco smoke. Prior evidence has shown that acrylamide causes cancer in rodents, yet epidemiological studies conducted to date are limited and, thus far, have yielded inconclusive data on association of human cancers with acrylamide exposure. In this study, we experimentally identify a novel and unique mutational signature imprinted by acrylamide through the effects of its reactive metabolite glycidamide. We next show that the glycidamide mutational signature is found in a full one-third of approximately 1600 tumor genomes corresponding to 19 human tumor types from 14 organs. The highest enrichment of the glycidamide signature was observed in the cancers of the lung (88
LB  - PUB:(DE-HGF)16
C6  - pmid:30846532
DO  - DOI:10.1101/gr.242453.118
UR  - https://inrepo02.dkfz.de/record/143430
ER  -