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@ARTICLE{Zhivagui:143430,
      author       = {M. Zhivagui and A. W. T. Ng and M. Ardin and M. I.
                      Churchwell and M. Pandey and C. Renard and S. Villar and V.
                      Cahais and A. Robitaille and L. Bouaoun and A. Heguy and K.
                      Z. Guyton and M. R. Stampfer and J. McKay and M.
                      Hollstein$^*$ and M. Olivier and S. G. Rozen and F. A.
                      Beland and M. Korenjak and J. Zavadil},
      title        = {{E}xperimental and pan-cancer genome analyses reveal
                      widespread contribution of acrylamide exposure to
                      carcinogenesis in humans.},
      journal      = {Genome research},
      volume       = {29},
      number       = {4},
      issn         = {1549-5469},
      address      = {Cold Spring Harbor, NY},
      publisher    = {Laboratory Press},
      reportid     = {DKFZ-2019-01018},
      pages        = {521 - 531},
      year         = {2019},
      abstract     = {Humans are frequently exposed to acrylamide, a probable
                      human carcinogen found in commonplace sources such as most
                      heated starchy foods or tobacco smoke. Prior evidence has
                      shown that acrylamide causes cancer in rodents, yet
                      epidemiological studies conducted to date are limited and,
                      thus far, have yielded inconclusive data on association of
                      human cancers with acrylamide exposure. In this study, we
                      experimentally identify a novel and unique mutational
                      signature imprinted by acrylamide through the effects of its
                      reactive metabolite glycidamide. We next show that the
                      glycidamide mutational signature is found in a full
                      one-third of approximately 1600 tumor genomes corresponding
                      to 19 human tumor types from 14 organs. The highest
                      enrichment of the glycidamide signature was observed in the
                      cancers of the lung $(88\%$ of the interrogated tumors),
                      liver $(73\%),$ kidney $(>70\%),$ bile duct $(57\%),$ cervix
                      $(50\%),$ and, to a lesser extent, additional cancer types.
                      Overall, our study reveals an unexpectedly extensive
                      contribution of acrylamide-associated mutagenesis to human
                      cancers.},
      cin          = {C016},
      ddc          = {540},
      cid          = {I:(DE-He78)C016-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30846532},
      doi          = {10.1101/gr.242453.118},
      url          = {https://inrepo02.dkfz.de/record/143430},
}