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@ARTICLE{Perna:143472,
      author       = {L. Perna$^*$ and H. W. Wahl and J. Weberpals$^*$ and L.
                      Jansen$^*$ and U. Mons$^*$ and B. Schöttker$^*$ and H.
                      Brenner$^*$},
      title        = {{I}ncident depression and mortality among people with
                      different types of dementia: results from a longitudinal
                      cohort study.},
      journal      = {Social psychiatry and psychiatric epidemiology},
      volume       = {54},
      number       = {7},
      issn         = {1433-9285},
      address      = {Heidelberg},
      publisher    = {Springer},
      reportid     = {DKFZ-2019-01060},
      pages        = {793-801},
      year         = {2019},
      abstract     = {The aim of this study was to investigate the independent
                      and combined association of incident depression and dementia
                      with mortality and to explore whether the magnitude of the
                      association varies according to different types of dementia,
                      including Alzheimer's disease and vascular dementia.The
                      study was based on a population-based longitudinal cohort
                      consisting of 9940 participants at baseline and followed for
                      over 14 years. The sample used for the analyses included
                      6114 participants with available information on diagnosis of
                      incident dementia and depression. For survival analyses, Cox
                      regression models with incident dementia (n = 293;
                      $5\%)$ and incident depression (n = 746; $12\%)$ as
                      time-dependent variables were used.Cox models adjusted for
                      relevant confounders indicated that comorbidity of incident
                      vascular dementia and incident depression was associated
                      with a much higher mortality risk (HR 6.99; $95\%$ CI
                      3.84-12.75) than vascular dementia in the absence of
                      depression (HR 2.80; $95\%$ CI 1.92-4.08). In contrast,
                      estimates for comorbidity of Alzheimer's disease and
                      depression were slightly lower than those for Alzheimer in
                      absence of depression (HR 3.56; $95\%$ CI 1.83-6.92 and HR
                      4.19; $95\%$ CI 2.97-5.90, respectively). Incident
                      depression in the absence of incident dementia was only
                      weakly associated with mortality.These findings indicate
                      that depression and vascular dementia might have synergistic
                      effects on mortality. The results have relevant public
                      health implications for prevention, routine screening for
                      and early treatment of depression among older people,
                      especially those at risk of vascular dementia.},
      cin          = {C070 / C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30840093},
      doi          = {10.1007/s00127-019-01683-0},
      url          = {https://inrepo02.dkfz.de/record/143472},
}