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@ARTICLE{Schbel:143475,
      author       = {R. Schübel$^*$ and T. Nonnenmacher and D. Sookthai$^*$ and
                      S. Gonzalez Maldonado$^*$ and S. A. Sowah$^*$ and O. von
                      Stackelberg and C. L. Schlett and M. Grafetstätter$^*$ and
                      D. Nabers$^*$ and T. S. Johnson$^*$ and R. Kirsten and C. M.
                      Ulrich and R. Kaaks$^*$ and H.-U. Kauczor and T. Kühn$^*$
                      and J. Nattenmüller},
      title        = {{S}imilar {W}eight {L}oss {I}nduces {G}reater
                      {I}mprovements in {I}nsulin {S}ensitivity and {L}iver
                      {F}unction among {I}ndividuals with {NAFLD} {C}ompared to
                      {I}ndividuals without {NAFLD}.},
      journal      = {Nutrients},
      volume       = {11},
      number       = {3},
      issn         = {2072-6643},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2019-01063},
      pages        = {544},
      year         = {2019},
      abstract     = {Preliminary evidence suggests that weight loss among obese
                      has differential metabolic effects depending on the presence
                      of non-alcoholic fatty liver disease (NAFLD). We assessed
                      whether NAFLD predisposes to differential changes in liver
                      fat content, liver function, and metabolic parameters upon
                      diet-induced weight loss in a 50-week intervention trial.143
                      overweight and obese non-smokers underwent a 12-week dietary
                      intervention and a 38-week follow-up. Diet-induced changes
                      in anthropometric measures, circulating biomarkers, and
                      magnetic resonance (MR)-derived liver fat content and
                      adipose tissue volumes were evaluated by mixed linear models
                      stratifying by NAFLD at baseline.The prevalence of NAFLD at
                      baseline was $52\%.$ Diet-induced weight loss after 12
                      (NAFLD: 4.8 ± $0.5\%,$ No NAFLD: 5.1 ± $0.5\%)$ and 50
                      weeks (NAFLD: 3.5 ± $0.7\%,$ No NAFLD: 3.5 ± $0.9\%)$ was
                      similar in both groups, while the decrease in liver fat was
                      significantly greater in the NAFLD group (week 12: 32.9 ±
                      $9.5\%$ vs. 6.3 ± $4.0\%;$ week 50: 23.3 ± $4.4\%$ vs. 5.0
                      ± $4.2\%).$ Decreases in biomarkers of liver dysfunction
                      (GGT, ALT, AST) and HOMA IR were also significantly greater
                      in the NAFLD group. Other metabolic parameters showed no
                      significant differences.Our data suggest that individuals
                      with NAFLD show greater improvements of liver function and
                      insulin sensitivity after moderate diet-induced weight loss
                      than individuals without NAFLD.},
      cin          = {C020 / E130},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)E130-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30836637},
      doi          = {10.3390/nu11030544},
      url          = {https://inrepo02.dkfz.de/record/143475},
}