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000143483 0247_ $$2ISSN$$a0148-6403
000143483 0247_ $$2ISSN$$a1043-3074
000143483 0247_ $$2ISSN$$a1097-0347
000143483 0247_ $$2ISSN$$a1930-2398
000143483 037__ $$aDKFZ-2019-01071
000143483 041__ $$aeng
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000143483 1001_ $$00000-0002-0278-7228$$aMoratin, Julius$$b0
000143483 245__ $$aUpregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma.
000143483 260__ $$aNew York, NY [u.a.]$$bWiley Interscience$$c2019
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000143483 520__ $$aThis study aimed on evaluating the expression levels of the immune checkpoint proteins, PD-L1 and PD-L2, in tissue specimens of 175 oral squamous cell carcinomas (OSCC) and 33 corresponding lymph node metastases (LNM).Tissue microarrays of primary OSCC and matched LNM were investigated via immunohistochemistry regarding PD-L1/PD-L2 expression. Results were compared for primary tumors and corresponding metastases and correlated with clinicopathological data.PD-L1 expression in cancer cells correlated significantly with tumor size, and the presence of regional metastases (P < 0.01). PD-L1 expression was significantly higher in metastases as compared to primary OSCC (P < 0.05). Overall survival was significantly worse in patients with higher levels of PD-L1 and PD-L2 score (P < 0.05).This is the first publication to compare PD-L1 and PD-L2 expression in primary OSCC and matched LNM. The results indicate that anti-PD-1 therapy may be of therapeutic use even in early stage OSCC to prevent further progression.
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000143483 7001_ $$aMetzger, Karl$$b1
000143483 7001_ $$aSafaltin, Ayse$$b2
000143483 7001_ $$aHerpel, Esther$$b3
000143483 7001_ $$aHoffmann, Jürgen$$b4
000143483 7001_ $$aFreier, Kolja$$b5
000143483 7001_ $$0P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f$$aHess, Jochen$$b6$$udkfz
000143483 7001_ $$00000-0001-5017-0815$$aHorn, Dominik$$b7
000143483 773__ $$0PERI:(DE-600)2001440-5$$a10.1002/hed.25713$$n8$$p2484-2491$$tHead & neck$$v41$$x1043-3074$$y2019
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000143483 9141_ $$y2019
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