TY  - JOUR
AU  - Moratin, Julius
AU  - Metzger, Karl
AU  - Safaltin, Ayse
AU  - Herpel, Esther
AU  - Hoffmann, Jürgen
AU  - Freier, Kolja
AU  - Hess, Jochen
AU  - Horn, Dominik
TI  - Upregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma.
JO  - Head & neck
VL  - 41
IS  - 8
SN  - 1043-3074
CY  - New York, NY [u.a.]
PB  - Wiley Interscience
M1  - DKFZ-2019-01071
SP  - 2484-2491
PY  - 2019
AB  - This study aimed on evaluating the expression levels of the immune checkpoint proteins, PD-L1 and PD-L2, in tissue specimens of 175 oral squamous cell carcinomas (OSCC) and 33 corresponding lymph node metastases (LNM).Tissue microarrays of primary OSCC and matched LNM were investigated via immunohistochemistry regarding PD-L1/PD-L2 expression. Results were compared for primary tumors and corresponding metastases and correlated with clinicopathological data.PD-L1 expression in cancer cells correlated significantly with tumor size, and the presence of regional metastases (P < 0.01). PD-L1 expression was significantly higher in metastases as compared to primary OSCC (P < 0.05). Overall survival was significantly worse in patients with higher levels of PD-L1 and PD-L2 score (P < 0.05).This is the first publication to compare PD-L1 and PD-L2 expression in primary OSCC and matched LNM. The results indicate that anti-PD-1 therapy may be of therapeutic use even in early stage OSCC to prevent further progression.
LB  - PUB:(DE-HGF)16
C6  - pmid:30821864
DO  - DOI:10.1002/hed.25713
UR  - https://inrepo02.dkfz.de/record/143483
ER  -