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| Home > Publications database > Upregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma. > print |
| 001 | 143483 | ||
| 005 | 20240229112554.0 | ||
| 024 | 7 | _ | |a 10.1002/hed.25713 |2 doi |
| 024 | 7 | _ | |a pmid:30821864 |2 pmid |
| 024 | 7 | _ | |a 0148-6403 |2 ISSN |
| 024 | 7 | _ | |a 1043-3074 |2 ISSN |
| 024 | 7 | _ | |a 1097-0347 |2 ISSN |
| 024 | 7 | _ | |a 1930-2398 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2019-01071 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Moratin, Julius |0 0000-0002-0278-7228 |b 0 |
| 245 | _ | _ | |a Upregulation of PD-L1 and PD-L2 in neck node metastases of head and neck squamous cell carcinoma. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2019 |b Wiley Interscience |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1565098283_2959 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a This study aimed on evaluating the expression levels of the immune checkpoint proteins, PD-L1 and PD-L2, in tissue specimens of 175 oral squamous cell carcinomas (OSCC) and 33 corresponding lymph node metastases (LNM).Tissue microarrays of primary OSCC and matched LNM were investigated via immunohistochemistry regarding PD-L1/PD-L2 expression. Results were compared for primary tumors and corresponding metastases and correlated with clinicopathological data.PD-L1 expression in cancer cells correlated significantly with tumor size, and the presence of regional metastases (P < 0.01). PD-L1 expression was significantly higher in metastases as compared to primary OSCC (P < 0.05). Overall survival was significantly worse in patients with higher levels of PD-L1 and PD-L2 score (P < 0.05).This is the first publication to compare PD-L1 and PD-L2 expression in primary OSCC and matched LNM. The results indicate that anti-PD-1 therapy may be of therapeutic use even in early stage OSCC to prevent further progression. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Metzger, Karl |b 1 |
| 700 | 1 | _ | |a Safaltin, Ayse |b 2 |
| 700 | 1 | _ | |a Herpel, Esther |b 3 |
| 700 | 1 | _ | |a Hoffmann, Jürgen |b 4 |
| 700 | 1 | _ | |a Freier, Kolja |b 5 |
| 700 | 1 | _ | |a Hess, Jochen |0 P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f |b 6 |u dkfz |
| 700 | 1 | _ | |a Horn, Dominik |0 0000-0001-5017-0815 |b 7 |
| 773 | _ | _ | |a 10.1002/hed.25713 |0 PERI:(DE-600)2001440-5 |n 8 |p 2484-2491 |t Head & neck |v 41 |y 2019 |x 1043-3074 |
| 909 | C | O | |o oai:inrepo02.dkfz.de:143483 |p VDB |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 6 |6 P:(DE-He78)2e5f34f1c58eda4787a14c9dc139ca5f |
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| 914 | 1 | _ | |y 2019 |
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| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b HEAD NECK-J SCI SPEC : 2017 |
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