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@ARTICLE{PerezCornago:143493,
author = {A. Perez-Cornago and I. Huybrechts and P. N. Appleby and J.
A. Schmidt and F. L. Crowe and K. Overvad and A. Tjønneland
and T. Kühn$^*$ and V. Katzke$^*$ and A. Trichopoulou and
A. Karakatsani and E. Peppa and S. Grioni and D. Palli and
C. Sacerdote and R. Tumino and H. B. Bueno-de-Mesquita and
N. Larrañaga and M.-J. Sánchez and J. R. Quirós and E.
Ardanaz and M.-D. Chirlaque and A. Agudo and A. Bjartell and
P. Wallström and V. Chajes and K. K. Tsilidis and D. Aune
and E. Riboli and R. C. Travis and T. J. Key},
title = {{I}ntake of individual fatty acids and risk of prostate
cancer in the {E}uropean prospective investigation into
cancer and nutrition.},
journal = {International journal of cancer},
volume = {146},
number = {1},
issn = {1097-0215},
address = {Bognor Regis},
publisher = {Wiley-Liss},
reportid = {DKFZ-2019-01080},
pages = {44-57},
year = {2020},
note = {146(1):44-57},
abstract = {The associations of individual dietary fatty acids with
prostate cancer risk have not been examined comprehensively.
We examined the prospective association of individual
dietary fatty acids with prostate cancer risk overall, by
tumor subtypes, and prostate cancer death. 142,239 men from
the European Prospective Investigation into Cancer and
Nutrition who were free from cancer at recruitment were
included. Dietary intakes of individual fatty acids were
estimated using center-specific validated dietary
questionnaires at baseline and calibrated with 24-h recalls.
Multivariable Cox regression models were used to estimate
hazard ratios (HRs) and $95\%$ confidence intervals (CIs).
After an average follow-up of 13.9 years, 7,036 prostate
cancer cases and 936 prostate cancer deaths were
ascertained. Intakes of individual fatty acids were not
related to overall prostate cancer risk. There was evidence
of heterogeneity in the association of some short chain
saturated fatty acids with prostate cancer risk by tumor
stage (pheterogeneity < 0.015), with a positive
association with risk of advanced stage disease for butyric
acid (4:0; HR1SD = 1.08; $95\%CI = 1.01-1.15;$
p-trend = 0.026). There were no associations with fatal
prostate cancer, with the exception of a slightly higher
risk for those who consumed more eicosenoic acid (22:1n-9c;
HR1SD = 1.05; 1.00-1.11; p-trend = 0.048) and
eicosapentaenoic acid (20:5n-3c; HR1SD = 1.07; 1.00-1.14;
p-trend = 0.045). There was no evidence that dietary
intakes of individual fatty acids were associated with
overall prostate cancer risk. However, a higher intake of
butyric acid might be associated with a higher risk of
advanced, whereas intakes of eicosenoic and eicosapentaenoic
acids might be positively associated with fatal prostate
cancer risk.},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30807653},
doi = {10.1002/ijc.32233},
url = {https://inrepo02.dkfz.de/record/143493},
}