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000143499 1001_ $$aFiorito, Giovanni$$b0
000143499 245__ $$aSocioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.
000143499 260__ $$a[S.l.]$$bImpact Journals, LLC$$c2019
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000143499 520__ $$aDifferences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.
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000143499 7001_ $$aMcCrory, Cathal$$b1
000143499 7001_ $$aRobinson, Oliver$$b2
000143499 7001_ $$aCarmeli, Cristian$$b3
000143499 7001_ $$aRosales, Carolina Ochoa$$b4
000143499 7001_ $$0P:(DE-He78)6a8f87626cb610618a60d742677284cd$$aZhang, Yan$$b5$$udkfz
000143499 7001_ $$aColicino, Elena$$b6
000143499 7001_ $$aDugué, Pierre-Antoine$$b7
000143499 7001_ $$aArtaud, Fanny$$b8
000143499 7001_ $$aMcKay, Gareth J$$b9
000143499 7001_ $$aJeong, Ayoung$$b10
000143499 7001_ $$aMishra, Pashupati P$$b11
000143499 7001_ $$aNøst, Therese H$$b12
000143499 7001_ $$aKrogh, Vittorio$$b13
000143499 7001_ $$aPanico, Salvatore$$b14
000143499 7001_ $$aSacerdote, Carlotta$$b15
000143499 7001_ $$aTumino, Rosario$$b16
000143499 7001_ $$aPalli, Domenico$$b17
000143499 7001_ $$aMatullo, Giuseppe$$b18
000143499 7001_ $$aGuarrera, Simonetta$$b19
000143499 7001_ $$aGandini, Martina$$b20
000143499 7001_ $$aBochud, Murielle$$b21
000143499 7001_ $$aDermitzakis, Emmanouil$$b22
000143499 7001_ $$aMuka, Taulant$$b23
000143499 7001_ $$aSchwartz, Joel$$b24
000143499 7001_ $$aVokonas, Pantel S$$b25
000143499 7001_ $$aJust, Allan$$b26
000143499 7001_ $$aHodge, Allison M$$b27
000143499 7001_ $$aGiles, Graham G$$b28
000143499 7001_ $$aSouthey, Melissa C$$b29
000143499 7001_ $$aHurme, Mikko A$$b30
000143499 7001_ $$aYoung, Ian$$b31
000143499 7001_ $$aMcKnight, Amy Jayne$$b32
000143499 7001_ $$aKunze, Sonja$$b33
000143499 7001_ $$aWaldenberger, Melanie$$b34
000143499 7001_ $$aPeters, Annette$$b35
000143499 7001_ $$aSchwettmann, Lars$$b36
000143499 7001_ $$aLund, Eiliv$$b37
000143499 7001_ $$aBaccarelli, Andrea$$b38
000143499 7001_ $$aMilne, Roger L$$b39
000143499 7001_ $$aKenny, Rose A$$b40
000143499 7001_ $$aElbaz, Alexis$$b41
000143499 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b42$$udkfz
000143499 7001_ $$aKee, Frank$$b43
000143499 7001_ $$aVoortman, Trudy$$b44
000143499 7001_ $$aProbst-Hensch, Nicole$$b45
000143499 7001_ $$aLehtimäki, Terho$$b46
000143499 7001_ $$aElliot, Paul$$b47
000143499 7001_ $$aStringhini, Silvia$$b48
000143499 7001_ $$aVineis, Paolo$$b49
000143499 7001_ $$aPolidoro, Silvia$$b50
000143499 7001_ $$aConsortium, BIOS$$b51$$eCollaboration Author
000143499 7001_ $$aconsortium, Lifepath$$b52$$eCollaboration Author
000143499 773__ $$0PERI:(DE-600)2535337-8$$a10.18632/aging.101900$$gVol. 11, no. 7, p. 2045 - 2070$$n7$$p2045 - 2070$$tAging$$v11$$x1945-4589$$y2019
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