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@ARTICLE{Fiorito:143499,
      author       = {G. Fiorito and C. McCrory and O. Robinson and C. Carmeli
                      and C. O. Rosales and Y. Zhang$^*$ and E. Colicino and P.-A.
                      Dugué and F. Artaud and G. J. McKay and A. Jeong and P. P.
                      Mishra and T. H. Nøst and V. Krogh and S. Panico and C.
                      Sacerdote and R. Tumino and D. Palli and G. Matullo and S.
                      Guarrera and M. Gandini and M. Bochud and E. Dermitzakis and
                      T. Muka and J. Schwartz and P. S. Vokonas and A. Just and A.
                      M. Hodge and G. G. Giles and M. C. Southey and M. A. Hurme
                      and I. Young and A. J. McKnight and S. Kunze and M.
                      Waldenberger and A. Peters and L. Schwettmann and E. Lund
                      and A. Baccarelli and R. L. Milne and R. A. Kenny and A.
                      Elbaz and H. Brenner$^*$ and F. Kee and T. Voortman and N.
                      Probst-Hensch and T. Lehtimäki and P. Elliot and S.
                      Stringhini and P. Vineis and S. Polidoro},
      collaboration = {B. Consortium and L. consortium},
      title        = {{S}ocioeconomic position, lifestyle habits and biomarkers
                      of epigenetic aging: a multi-cohort analysis.},
      journal      = {Aging},
      volume       = {11},
      number       = {7},
      issn         = {1945-4589},
      address      = {[S.l.]},
      publisher    = {Impact Journals, LLC},
      reportid     = {DKFZ-2019-01083},
      pages        = {2045 - 2070},
      year         = {2019},
      abstract     = {Differences in health status by socioeconomic position
                      (SEP) tend to be more evident at older ages, suggesting the
                      involvement of a biological mechanism responsive to the
                      accumulation of deleterious exposures across the lifespan.
                      DNA methylation (DNAm) has been proposed as a biomarker of
                      biological aging that conserves memory of endogenous and
                      exogenous stress during life.We examined the association of
                      education level, as an indicator of SEP, and
                      lifestyle-related variables with four biomarkers of
                      age-dependent DNAm dysregulation: the total number of
                      stochastic epigenetic mutations (SEMs) and three epigenetic
                      clocks (Horvath, Hannum and Levine), in 18 cohorts spanning
                      12 countries.The four biological aging biomarkers were
                      associated with education and different sets of risk factors
                      independently, and the magnitude of the effects differed
                      depending on the biomarker and the predictor. On average,
                      the effect of low education on epigenetic aging was
                      comparable with those of other lifestyle-related risk
                      factors (obesity, alcohol intake), with the exception of
                      smoking, which had a significantly stronger effect.Our study
                      shows that low education is an independent predictor of
                      accelerated biological (epigenetic) aging and that
                      epigenetic clocks appear to be good candidates for
                      disentangling the biological pathways underlying social
                      inequalities in healthy aging and longevity.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31009935},
      doi          = {10.18632/aging.101900},
      url          = {https://inrepo02.dkfz.de/record/143499},
}