000143500 001__ 143500
000143500 005__ 20240229112554.0
000143500 0247_ $$2doi$$a10.1016/j.jtho.2019.04.008
000143500 0247_ $$2pmid$$apmid:31009812
000143500 0247_ $$2ISSN$$a1556-0864
000143500 0247_ $$2ISSN$$a1556-1380
000143500 0247_ $$2altmetric$$aaltmetric:59583020
000143500 037__ $$aDKFZ-2019-01084
000143500 041__ $$aeng
000143500 082__ $$a610
000143500 1001_ $$aHung, Rayjean J$$b0
000143500 245__ $$aLung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 5P15.33 TERT-CLPTM1L Region.
000143500 260__ $$aAmsterdam$$bElsevier$$c2019
000143500 3367_ $$2DRIVER$$aarticle
000143500 3367_ $$2DataCite$$aOutput Types/Journal article
000143500 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1580298126_4462
000143500 3367_ $$2BibTeX$$aARTICLE
000143500 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000143500 3367_ $$00$$2EndNote$$aJournal Article
000143500 520__ $$aInherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer.We conducted a two-phase (discovery and replication) GWAS in never smokers of European descent. We further augmented the sample by performing a meta-analysis with never smokers from the recent OncoArray study, which resulted in a total of 3,636 cases and 6,295 controls. We also compare our findings with those in smokers with lung cancer.We detected three genome-wide statistically significant SNPs rs31490 (OR 0.769, 95% confidence interval (CI) [0.722-0.820], p-value 5.31x10-16), rs380286 (OR 0.770, 95% CI [0.723-0.820], p-value 4.32x10-16), and rs4975616 (OR 0.778, 95% CI [0.730-0.829], p-value 1.04x10-14). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never smoker Asian women, and risk of other cancers including breast, ovarian, colorectal and prostate.We found that genetic susceptibility to lung cancer in never smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease.
000143500 536__ $$0G:(DE-HGF)POF3-319H$$a319H - Addenda (POF3-319H)$$cPOF3-319H$$fPOF III$$x0
000143500 588__ $$aDataset connected to CrossRef, PubMed,
000143500 7001_ $$aSpitz, Margaret R$$b1
000143500 7001_ $$aHoulston, Richard S$$b2
000143500 7001_ $$aSchwartz, Ann G$$b3
000143500 7001_ $$aField, John K$$b4
000143500 7001_ $$aYing, Jun$$b5
000143500 7001_ $$aLi, Yafang$$b6
000143500 7001_ $$aHan, Younghun$$b7
000143500 7001_ $$aJi, Xuemei$$b8
000143500 7001_ $$aChen, Wei$$b9
000143500 7001_ $$aWu, Xifeng$$b10
000143500 7001_ $$aGorlov, Ivan P$$b11
000143500 7001_ $$aNa, Jie$$b12
000143500 7001_ $$ade Andrade, Mariza$$b13
000143500 7001_ $$aLiu, Geoffrey$$b14
000143500 7001_ $$aBrhane, Yonathan$$b15
000143500 7001_ $$aDiao, Nancy$$b16
000143500 7001_ $$aWenzlaff, Angela$$b17
000143500 7001_ $$aDavies, Michael P A$$b18
000143500 7001_ $$aLiloglou, Triantafillos$$b19
000143500 7001_ $$0P:(DE-HGF)0$$aTimofeeva, Maria$$b20
000143500 7001_ $$aMuley, Thomas$$b21
000143500 7001_ $$aRennert, Hedy$$b22
000143500 7001_ $$aSaliba, Walid$$b23
000143500 7001_ $$aRyan, Bríd M$$b24
000143500 7001_ $$aBowman, Elise$$b25
000143500 7001_ $$aBarros-Dios, Juan-Miguel$$b26
000143500 7001_ $$aPérez-Ríos, Mónica$$b27
000143500 7001_ $$aMorgenstern, Hal$$b28
000143500 7001_ $$aZienolddiny, Shanbeh$$b29
000143500 7001_ $$aSkaug, Vidar$$b30
000143500 7001_ $$aUgolini, Donatella$$b31
000143500 7001_ $$aBonassi, Stefano$$b32
000143500 7001_ $$avan der Heijden, Erik H F M$$b33
000143500 7001_ $$aTardon, Adonina$$b34
000143500 7001_ $$aBojesen, Stig E$$b35
000143500 7001_ $$aLandi, Maria Teresa$$b36
000143500 7001_ $$aJohansson, Mattias$$b37
000143500 7001_ $$aBickeböller, Heike$$b38
000143500 7001_ $$aArnold, Susanne$$b39
000143500 7001_ $$aLe Marchand, Loic$$b40
000143500 7001_ $$aMelander, Olle$$b41
000143500 7001_ $$aAndrew, Angeline$$b42
000143500 7001_ $$aGrankvist, Kjell$$b43
000143500 7001_ $$aCaporaso, Neil$$b44
000143500 7001_ $$aTeare, M Dawn$$b45
000143500 7001_ $$aSchabath, Matthew B$$b46
000143500 7001_ $$aAldrich, Melinda C$$b47
000143500 7001_ $$aKiemeney, Lambertus A$$b48
000143500 7001_ $$aWichmann, H-Erich$$b49
000143500 7001_ $$aLazarus, Philip$$b50
000143500 7001_ $$aMayordomo, Jose$$b51
000143500 7001_ $$aNeri, Monica$$b52
000143500 7001_ $$aHaugen, Aage$$b53
000143500 7001_ $$aZhang, Zuo-Feng$$b54
000143500 7001_ $$aRuano-Raviña, Alberto$$b55
000143500 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b56$$udkfz
000143500 7001_ $$aHarris, Curtis C$$b57
000143500 7001_ $$aOrlow, Irene$$b58
000143500 7001_ $$aRennert, Gadi$$b59
000143500 7001_ $$0P:(DE-He78)4981f4ef151aea881f38b33df8e35a21$$aRisch, Angela$$b60$$udkfz
000143500 7001_ $$aBrennan, Paul$$b61
000143500 7001_ $$aChristiani, David C$$b62
000143500 7001_ $$aAmos, Christopher I$$b63
000143500 7001_ $$aYang, Ping$$b64
000143500 7001_ $$aGorlova, Olga Y$$b65
000143500 773__ $$0PERI:(DE-600)2223437-8$$a10.1016/j.jtho.2019.04.008$$gp. S1556086419302898$$n8$$p1360-1369$$tJournal of thoracic oncology$$v14$$x1556-0864$$y2019
000143500 909CO $$ooai:inrepo02.dkfz.de:143500$$pVDB
000143500 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-HGF)0$$aDeutsches Krebsforschungszentrum$$b20$$kDKFZ
000143500 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b56$$kDKFZ
000143500 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4981f4ef151aea881f38b33df8e35a21$$aDeutsches Krebsforschungszentrum$$b60$$kDKFZ
000143500 9131_ $$0G:(DE-HGF)POF3-319H$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vAddenda$$x0
000143500 9141_ $$y2019
000143500 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz
000143500 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000143500 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000143500 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000143500 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ THORAC ONCOL : 2017
000143500 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000143500 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000143500 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000143500 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000143500 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000143500 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bJ THORAC ONCOL : 2017
000143500 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lKlinische Epidemiologie und Alternsforschung$$x0
000143500 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000143500 9201_ $$0I:(DE-He78)B370-20160331$$kB370$$lEpigenomik$$x2
000143500 980__ $$ajournal
000143500 980__ $$aVDB
000143500 980__ $$aI:(DE-He78)C070-20160331
000143500 980__ $$aI:(DE-He78)C120-20160331
000143500 980__ $$aI:(DE-He78)B370-20160331
000143500 980__ $$aUNRESTRICTED