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@ARTICLE{Hung:143500,
      author       = {R. J. Hung and M. R. Spitz and R. S. Houlston and A. G.
                      Schwartz and J. K. Field and J. Ying and Y. Li and Y. Han
                      and X. Ji and W. Chen and X. Wu and I. P. Gorlov and J. Na
                      and M. de Andrade and G. Liu and Y. Brhane and N. Diao and
                      A. Wenzlaff and M. P. A. Davies and T. Liloglou and M.
                      Timofeeva$^*$ and T. Muley and H. Rennert and W. Saliba and
                      B. M. Ryan and E. Bowman and J.-M. Barros-Dios and M.
                      Pérez-Ríos and H. Morgenstern and S. Zienolddiny and V.
                      Skaug and D. Ugolini and S. Bonassi and E. H. F. M. van der
                      Heijden and A. Tardon and S. E. Bojesen and M. T. Landi and
                      M. Johansson and H. Bickeböller and S. Arnold and L. Le
                      Marchand and O. Melander and A. Andrew and K. Grankvist and
                      N. Caporaso and M. D. Teare and M. B. Schabath and M. C.
                      Aldrich and L. A. Kiemeney and H.-E. Wichmann and P. Lazarus
                      and J. Mayordomo and M. Neri and A. Haugen and Z.-F. Zhang
                      and A. Ruano-Raviña and H. Brenner$^*$ and C. C. Harris and
                      I. Orlow and G. Rennert and A. Risch$^*$ and P. Brennan and
                      D. C. Christiani and C. I. Amos and P. Yang and O. Y.
                      Gorlova},
      title        = {{L}ung {C}ancer {R}isk in {N}ever {S}mokers of {E}uropean
                      {D}escent is {A}ssociated with {G}enetic {V}ariation in the
                      5{P}15.33 {TERT}-{CLPTM}1{L} {R}egion.},
      journal      = {Journal of thoracic oncology},
      volume       = {14},
      number       = {8},
      issn         = {1556-0864},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-01084},
      pages        = {1360-1369},
      year         = {2019},
      abstract     = {Inherited susceptibility to lung cancer risk in never
                      smokers is poorly understood. The major reason for this gap
                      in knowledge is that this disease is relatively uncommon
                      (except in Asians), making it difficult to assemble an
                      adequate study sample. In this study we conducted a
                      genome-wide association study (GWAS) on the largest, to
                      date, set of European-descent never smokers with lung
                      cancer.We conducted a two-phase (discovery and replication)
                      GWAS in never smokers of European descent. We further
                      augmented the sample by performing a meta-analysis with
                      never smokers from the recent OncoArray study, which
                      resulted in a total of 3,636 cases and 6,295 controls. We
                      also compare our findings with those in smokers with lung
                      cancer.We detected three genome-wide statistically
                      significant SNPs rs31490 (OR 0.769, $95\%$ confidence
                      interval (CI) [0.722-0.820], p-value 5.31x10-16), rs380286
                      (OR 0.770, $95\%$ CI [0.723-0.820], p-value 4.32x10-16), and
                      rs4975616 (OR 0.778, $95\%$ CI [0.730-0.829], p-value
                      1.04x10-14). All three mapped to Chromosome 5 CLPTM1L-TERT
                      region, previously shown to be associated with lung cancer
                      risk in smokers and in never smoker Asian women, and risk of
                      other cancers including breast, ovarian, colorectal and
                      prostate.We found that genetic susceptibility to lung cancer
                      in never smokers is associated to genetic variants with
                      pan-cancer risk effects. The comparison with smokers shows
                      that top variants previously shown to be associated with
                      lung cancer risk only confer risk in the presence of tobacco
                      exposure, underscoring the importance of gene-environment
                      interactions in the etiology of this disease.},
      cin          = {C070 / C120 / B370},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)B370-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31009812},
      doi          = {10.1016/j.jtho.2019.04.008},
      url          = {https://inrepo02.dkfz.de/record/143500},
}