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@ARTICLE{Herpertz:143501,
      author       = {S. C. Herpertz and M. M. Schmitgen and C. Fuchs and C. Roth
                      and R. C. Wolf and K. Bertsch and H. Flor and V.
                      Grinevich$^*$ and S. Boll},
      title        = {{O}xytocin {E}ffects on {P}ain {P}erception and {P}ain
                      {A}nticipation.},
      journal      = {The journal of pain},
      volume       = {20},
      number       = {10},
      issn         = {1526-5900},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-01085},
      pages        = {1187-1198},
      year         = {2019},
      abstract     = {There is an ongoing debate whether the neuropeptide
                      oxytocin (OT) modulates pain processing in humans. This
                      study differentiates behavioral and neuronal OT effects on
                      pain perception and pain anticipation by using a Pavlovian
                      conditioning paradigm. Forty-six males received intranasally
                      administered OT in a randomized double-blind,
                      placebo-controlled group design. Although OT exerted no
                      direct effect on perceived pain, OT was found to modulate
                      the blood-oxygen-level-dependent response in the ventral
                      striatum for painful versus warm unconditioned stimuli (US)
                      and to decrease activity in the anterior insula with
                      repeated thermal pain stimuli. Regarding pain anticipation,
                      OT increased responses to CSpain versus CSminus in the
                      nucleus accumbens. Furthermore, in the OT condition
                      increased correct expectations, particularly for the most
                      certain CS-US associations (CSminus and CSpain), were found
                      as well as greatest deactivations in the right posterior
                      insula in response to the least certain condition (CSwarm)
                      with posterior insula activity and correct expectancies
                      being positively correlated. In conclusion, OT appears to
                      have both, a direct effect on pain processing via the
                      ventral striatum and by inducing habituation in the anterior
                      insula as well as on pain anticipation by boostering
                      associative learning in general and the neuronal conditioned
                      fear of pain response in particular. PERSPECTIVE: The
                      neuropeptide oxytocin (OT) has recently raised the hope to
                      offer a novel avenue for modulating pain experience. This
                      study found OT to modulate pain processing and to facilitate
                      the anticipation of pain inspiring further research on OT
                      effects on the affective dimension of the pain experience.},
      cin          = {V078},
      ddc          = {610},
      cid          = {I:(DE-He78)V078-20160331},
      pnm          = {319H - Addenda (POF3-319H)},
      pid          = {G:(DE-HGF)POF3-319H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31009765},
      doi          = {10.1016/j.jpain.2019.04.002},
      url          = {https://inrepo02.dkfz.de/record/143501},
}