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000143503 0247_ $$2doi$$a10.1016/j.jhep.2018.12.014
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000143503 041__ $$aeng
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000143503 1001_ $$aBaumeister, Sebastian E$$b0
000143503 245__ $$aAssociation between physical activity and risk of hepatobiliary cancers: A multinational cohort study.
000143503 260__ $$a[S.l.]$$bWiley-Blackwell$$c2019
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000143503 520__ $$aTo date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection).In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38-0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33-0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC.These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity.In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption.
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000143503 7001_ $$aSchlesinger, Sabrina$$b1
000143503 7001_ $$aAleksandrova, Krasimira$$b2
000143503 7001_ $$aJochem, Carmen$$b3
000143503 7001_ $$aJenab, Mazda$$b4
000143503 7001_ $$aGunter, Marc J$$b5
000143503 7001_ $$aOvervad, Kim$$b6
000143503 7001_ $$aTjønneland, Anne$$b7
000143503 7001_ $$aBoutron-Ruault, Marie-Christine$$b8
000143503 7001_ $$aCarbonnel, Franck$$b9
000143503 7001_ $$aFournier, Agnès$$b10
000143503 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b11$$udkfz
000143503 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b12$$udkfz
000143503 7001_ $$aPischon, Tobias$$b13
000143503 7001_ $$aBoeing, Heiner$$b14
000143503 7001_ $$aTrichopoulou, Antonia$$b15
000143503 7001_ $$aBamia, Christina$$b16
000143503 7001_ $$aLa Vecchia, Carlo$$b17
000143503 7001_ $$aMasala, Giovanna$$b18
000143503 7001_ $$aPanico, Salvatore$$b19
000143503 7001_ $$aFasanelli, Francesca$$b20
000143503 7001_ $$aTumino, Rosario$$b21
000143503 7001_ $$aGrioni, Sara$$b22
000143503 7001_ $$aBueno de Mesquita, Bas$$b23
000143503 7001_ $$aVermeulen, Roel$$b24
000143503 7001_ $$aMay, Anne M$$b25
000143503 7001_ $$aBorch, Kristin B$$b26
000143503 7001_ $$aOyeyemi, Sunday O$$b27
000143503 7001_ $$aArdanaz, Eva$$b28
000143503 7001_ $$aRodríguez-Barranco, Miguel$$b29
000143503 7001_ $$aDolores Chirlaque López, María$$b30
000143503 7001_ $$aFelez-Nobrega, Mireia$$b31
000143503 7001_ $$aSonestedt, Emily$$b32
000143503 7001_ $$aOhlsson, Bodil$$b33
000143503 7001_ $$aHemmingsson, Oskar$$b34
000143503 7001_ $$aWerner, Mårten$$b35
000143503 7001_ $$aPerez-Cornago, Aurora$$b36
000143503 7001_ $$aFerrari, Pietro$$b37
000143503 7001_ $$aStepien, Magdalena$$b38
000143503 7001_ $$aFreisling, Heinz$$b39
000143503 7001_ $$aTsilidis, Konstantinos K$$b40
000143503 7001_ $$aWard, Heather$$b41
000143503 7001_ $$aRiboli, Elio$$b42
000143503 7001_ $$aWeiderpass, Elisabete$$b43
000143503 7001_ $$aLeitzmann, Michael F$$b44
000143503 773__ $$0PERI:(DE-600)2027112-8$$a10.1016/j.jhep.2018.12.014$$gVol. 70, no. 5, p. 885 - 892$$n5$$p885 - 892$$tJournal of hepatology$$v70$$x0168-8278$$y2019
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