TY  - JOUR
AU  - Baumeister, Sebastian E
AU  - Schlesinger, Sabrina
AU  - Aleksandrova, Krasimira
AU  - Jochem, Carmen
AU  - Jenab, Mazda
AU  - Gunter, Marc J
AU  - Overvad, Kim
AU  - Tjønneland, Anne
AU  - Boutron-Ruault, Marie-Christine
AU  - Carbonnel, Franck
AU  - Fournier, Agnès
AU  - Kühn, Tilman
AU  - Kaaks, Rudolf
AU  - Pischon, Tobias
AU  - Boeing, Heiner
AU  - Trichopoulou, Antonia
AU  - Bamia, Christina
AU  - La Vecchia, Carlo
AU  - Masala, Giovanna
AU  - Panico, Salvatore
AU  - Fasanelli, Francesca
AU  - Tumino, Rosario
AU  - Grioni, Sara
AU  - Bueno de Mesquita, Bas
AU  - Vermeulen, Roel
AU  - May, Anne M
AU  - Borch, Kristin B
AU  - Oyeyemi, Sunday O
AU  - Ardanaz, Eva
AU  - Rodríguez-Barranco, Miguel
AU  - Dolores Chirlaque López, María
AU  - Felez-Nobrega, Mireia
AU  - Sonestedt, Emily
AU  - Ohlsson, Bodil
AU  - Hemmingsson, Oskar
AU  - Werner, Mårten
AU  - Perez-Cornago, Aurora
AU  - Ferrari, Pietro
AU  - Stepien, Magdalena
AU  - Freisling, Heinz
AU  - Tsilidis, Konstantinos K
AU  - Ward, Heather
AU  - Riboli, Elio
AU  - Weiderpass, Elisabete
AU  - Leitzmann, Michael F
TI  - Association between physical activity and risk of hepatobiliary cancers: A multinational cohort study.
JO  - Journal of hepatology
VL  - 70
IS  - 5
SN  - 0168-8278
CY  - [S.l.]
PB  - Wiley-Blackwell
M1  - DKFZ-2019-01087
SP  - 885 - 892
PY  - 2019
AB  - To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection).In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:30582978
DO  - DOI:10.1016/j.jhep.2018.12.014
UR  - https://inrepo02.dkfz.de/record/143503
ER  -