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@ARTICLE{Baumeister:143503,
      author       = {S. E. Baumeister and S. Schlesinger and K. Aleksandrova and
                      C. Jochem and M. Jenab and M. J. Gunter and K. Overvad and
                      A. Tjønneland and M.-C. Boutron-Ruault and F. Carbonnel and
                      A. Fournier and T. Kühn$^*$ and R. Kaaks$^*$ and T. Pischon
                      and H. Boeing and A. Trichopoulou and C. Bamia and C. La
                      Vecchia and G. Masala and S. Panico and F. Fasanelli and R.
                      Tumino and S. Grioni and B. Bueno de Mesquita and R.
                      Vermeulen and A. M. May and K. B. Borch and S. O. Oyeyemi
                      and E. Ardanaz and M. Rodríguez-Barranco and M. Dolores
                      Chirlaque López and M. Felez-Nobrega and E. Sonestedt and
                      B. Ohlsson and O. Hemmingsson and M. Werner and A.
                      Perez-Cornago and P. Ferrari and M. Stepien and H. Freisling
                      and K. K. Tsilidis and H. Ward and E. Riboli and E.
                      Weiderpass and M. F. Leitzmann},
      title        = {{A}ssociation between physical activity and risk of
                      hepatobiliary cancers: {A} multinational cohort study.},
      journal      = {Journal of hepatology},
      volume       = {70},
      number       = {5},
      issn         = {0168-8278},
      address      = {[S.l.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {DKFZ-2019-01087},
      pages        = {885 - 892},
      year         = {2019},
      abstract     = {To date, evidence on the association between physical
                      activity and risk of hepatobiliary cancers has been
                      inconclusive. We examined this association in the European
                      Prospective Investigation into Cancer and Nutrition cohort
                      (EPIC).We identified 275 hepatocellular carcinoma (HCC)
                      cases, 93 intrahepatic bile duct cancers (IHBCs), and 164
                      non-gallbladder extrahepatic bile duct cancers (NGBCs) among
                      467,336 EPIC participants (median follow-up 14.9 years).
                      We estimated cause-specific hazard ratios (HRs) for total
                      physical activity and vigorous physical activity and
                      performed mediation analysis and secondary analyses to
                      assess robustness to confounding (e.g. due to hepatitis
                      virus infection).In the EPIC cohort, the
                      multivariable-adjusted HR of HCC was 0.55 $(95\%$ CI
                      0.38-0.80) comparing active and inactive individuals.
                      Regarding vigorous physical activity, for those reporting
                      >2 hours/week compared to those with no vigorous activity,
                      the HR for HCC was 0.50 $(95\%$ CI 0.33-0.76). Estimates
                      were similar in sensitivity analyses for confounding. Total
                      and vigorous physical activity were unrelated to IHBC and
                      NGBC. In mediation analysis, waist circumference explained
                      about $40\%$ and body mass index $30\%$ of the overall
                      association of total physical activity and HCC.These
                      findings suggest an inverse association between physical
                      activity and risk of HCC, which is potentially mediated by
                      obesity.In a pan-European study of 467,336 men and women, we
                      found that physical activity is associated with a reduced
                      risk of developing liver cancers over the next decade. This
                      risk was independent of other liver cancer risk factors, and
                      did not vary by age, gender, smoking status, body weight,
                      and alcohol consumption.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30582978},
      doi          = {10.1016/j.jhep.2018.12.014},
      url          = {https://inrepo02.dkfz.de/record/143503},
}