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000143508 1001_ $$0P:(DE-He78)a4340add02b610f9dbdba2dc909cbd09$$aDelacher, Michael$$b0$$eFirst author
000143508 245__ $$aRbpj expression in regulatory T cells is critical for restraining TH2 responses.
000143508 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000143508 520__ $$aThe transcriptional regulator Rbpj is involved in T-helper (TH) subset polarization, but its function in Treg cells remains unclear. Here we show that Treg-specific Rbpj deletion leads to splenomegaly and lymphadenopathy despite increased numbers of Treg cells with a polyclonal TCR repertoire. A specific defect of Rbpj-deficient Treg cells in controlling TH2 polarization and B cell responses is observed, leading to the spontaneous formation of germinal centers and a TH2-associated immunoglobulin class switch. The observed phenotype is environment-dependent and can be induced by infection with parasitic nematodes. Rbpj-deficient Treg cells adopt open chromatin landscapes and gene expression profiles reminiscent of tissue-derived TH2-polarized Treg cells, with a prevailing signature of the transcription factor Gata-3. Taken together, our study suggests that Treg cells require Rbpj to specifically restrain TH2 responses, including their own excessive TH2-like differentiation potential.
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000143508 7001_ $$00000-0002-0522-202X$$aSchmidl, Christian$$b1
000143508 7001_ $$aHerzig, Yonatan$$b2
000143508 7001_ $$00000-0001-6199-4908$$aBreloer, Minka$$b3
000143508 7001_ $$aHartmann, Wiebke$$b4
000143508 7001_ $$0P:(DE-He78)79264e5eb093c3b6fe517e4ca29da19b$$aBrunk, Fabian$$b5
000143508 7001_ $$0P:(DE-He78)06354828cd2bda194bba64ffa5303d6a$$aKägebein, Danny$$b6
000143508 7001_ $$0P:(DE-He78)4d320583e7adaedcb8374d787eb6bfe5$$aTräger, Ulrike$$b7
000143508 7001_ $$0P:(DE-He78)24f65e08387eafe8f511b710e366fdf4$$aHofer, Ann-Cathrin$$b8
000143508 7001_ $$aBittner, Sebastian$$b9
000143508 7001_ $$0P:(DE-He78)ff4024f7bc236e7897d9c18ee19c451f$$aWeichenhan, Dieter$$b10
000143508 7001_ $$00000-0003-4920-551X$$aImbusch, Charles D$$b11
000143508 7001_ $$0P:(DE-He78)2f34b89d62d5e5c651aa1e683844b092$$aHotz-Wagenblatt, Agnes$$b12
000143508 7001_ $$0P:(DE-He78)743a4a82daab55306a2c88b9f6bf8c2f$$aHielscher, Thomas$$b13
000143508 7001_ $$0P:(DE-He78)75fed3121e92379462cce5d2267320b7$$aBreiling, Achim$$b14
000143508 7001_ $$0P:(DE-He78)616706c4d6f7bdf68b30893f860cbb2b$$aFederico, Giuseppina$$b15
000143508 7001_ $$0P:(DE-He78)00a2ea610aee4a8fca32908fc3d02e91$$aGröne, Hermann-Josef$$b16
000143508 7001_ $$aSchmid, Roland M$$b17
000143508 7001_ $$00000-0003-3992-932X$$aRehli, Michael$$b18
000143508 7001_ $$aAbramson, Jakub$$b19
000143508 7001_ $$0P:(DE-He78)f0638edf1d3f61c0d7ebb587f511733f$$aFeuerer, Markus$$b20$$eLast author
000143508 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-09276-w$$gVol. 10, no. 1, p. 1621$$n1$$p1621$$tNature Communications$$v10$$x2041-1723$$y2019
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