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@ARTICLE{Chen:143557,
      author       = {H. Chen$^*$ and C. Stock$^*$ and M. Hoffmeister$^*$ and H.
                      Brenner$^*$},
      title        = {{O}ptimal age for screening colonoscopy: a modeling
                      study.g110},
      journal      = {Gastrointestinal endoscopy},
      volume       = {89},
      number       = {5},
      issn         = {0016-5107},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-01138},
      pages        = {1017 - 1025.e12},
      year         = {2019},
      abstract     = {Recent guidelines on colorectal cancer (CRC) screening
                      recommend starting screening earlier than before. We
                      performed a simulation study to examine and compare the
                      optimal ages to have once-only screening colonoscopy and
                      repeated colonoscopies.A Markov model was set up using data
                      from the German national screening colonoscopy registry to
                      simulate the natural history of the adenoma-carcinoma
                      process. CRC deaths and years of potential life lost (YPLL)
                      for a hypothetical unscreened 50-year-old German population
                      were estimated for a single screening colonoscopy or 2 or 3
                      screening colonoscopies with 10-year intervals at various
                      ages.One single screening colonoscopy performed between 50
                      and 65 years of age was expected to reduce CRC death by
                      $49\%$ to $69\%$ and YPLL by $51\%$ to $68\%.$ An inverted
                      U-shaped association was found between screening age and
                      proportion of CRC deaths or YPLL prevented. The optimal age
                      for once-only colonoscopy that yielded the highest
                      reductions in YPLL was around 54 years for men and 56 years
                      for women. Estimates were approximately 6 to 8 years higher
                      when proportions of CRC deaths prevented were examined. For
                      2 or 3 screening colonoscopies, the optimal starting age
                      fell to around 50 years or even younger for both
                      genders.Based on the YPLL estimates, in a high CRC incidence
                      and high life expectancy country like Germany, the optimal
                      age for once-only screening colonoscopy is around 55 years
                      and possibly slightly younger for men than for women. When 2
                      or more screening colonoscopies are offered with 10-year
                      intervals, screening should start at age 50 at the latest or
                      possibly even younger for both genders.},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30639539},
      doi          = {10.1016/j.gie.2018.12.021},
      url          = {https://inrepo02.dkfz.de/record/143557},
}