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| 001 | 143557 | ||
| 005 | 20240229112557.0 | ||
| 024 | 7 | _ | |a 10.1016/j.gie.2018.12.021 |2 doi |
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| 100 | 1 | _ | |a Chen, Hongda |0 P:(DE-He78)03c284fb24dee4c82200ce43e1e0340f |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Optimal age for screening colonoscopy: a modeling study.g110 |
| 260 | _ | _ | |a New York, NY |c 2019 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Recent guidelines on colorectal cancer (CRC) screening recommend starting screening earlier than before. We performed a simulation study to examine and compare the optimal ages to have once-only screening colonoscopy and repeated colonoscopies.A Markov model was set up using data from the German national screening colonoscopy registry to simulate the natural history of the adenoma-carcinoma process. CRC deaths and years of potential life lost (YPLL) for a hypothetical unscreened 50-year-old German population were estimated for a single screening colonoscopy or 2 or 3 screening colonoscopies with 10-year intervals at various ages.One single screening colonoscopy performed between 50 and 65 years of age was expected to reduce CRC death by 49% to 69% and YPLL by 51% to 68%. An inverted U-shaped association was found between screening age and proportion of CRC deaths or YPLL prevented. The optimal age for once-only colonoscopy that yielded the highest reductions in YPLL was around 54 years for men and 56 years for women. Estimates were approximately 6 to 8 years higher when proportions of CRC deaths prevented were examined. For 2 or 3 screening colonoscopies, the optimal starting age fell to around 50 years or even younger for both genders.Based on the YPLL estimates, in a high CRC incidence and high life expectancy country like Germany, the optimal age for once-only screening colonoscopy is around 55 years and possibly slightly younger for men than for women. When 2 or more screening colonoscopies are offered with 10-year intervals, screening should start at age 50 at the latest or possibly even younger for both genders. |
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| 700 | 1 | _ | |a Stock, Christian |0 P:(DE-He78)908880209a64ea539ae8dc5fdb7e0a91 |b 1 |u dkfz |
| 700 | 1 | _ | |a Hoffmeister, Michael |0 P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f |b 2 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 3 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1016/j.gie.2018.12.021 |g Vol. 89, no. 5, p. 1017 - 1025.e12 |0 PERI:(DE-600)2006253-9 |n 5 |p 1017 - 1025.e12 |t Gastrointestinal endoscopy |v 89 |y 2019 |x 0016-5107 |
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