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@ARTICLE{Mokhtarzade:143561,
      author       = {M. Mokhtarzade and H. Agha-Alinejad and R. W. Motl and R.
                      Negaresh and J. S. Baker and P. Zimmer$^*$},
      title        = {{W}eight control and physical exercise in people with
                      multiple sclerosis: {C}urrent knowledge and future
                      perspectives.},
      journal      = {Complementary therapies in medicine},
      volume       = {43},
      issn         = {0965-2299},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2019-01142},
      pages        = {240 - 246},
      year         = {2019},
      abstract     = {There is extensive data supporting a high prevalence of
                      both overweight and obesity status in people with multiple
                      sclerosis, and increases in body mass index has been
                      associated with an increased risk of multiple sclerosis.
                      Body composition may influence the course, treatment and
                      management of multiple sclerosis. One proposed strategy for
                      managing overweight and obesity status and associated
                      secondary effects in people with multiple sclerosis involves
                      increasing the levels of physical activity. In fact,
                      increased levels of physical activity affect various
                      physiological (endurance capacity, strength, balance) and
                      biological processes (fat oxidation, insulin sensitivity,
                      anti-inflammation, neurotrophic factors) which are known to
                      be dysfunctional in multiple sclerosis and which may worsen
                      with increases in obesity. When designing personalized
                      exercise programs it should be kept in mind that current
                      exercise recommendations for people with multiple sclerosis
                      should exceed energy expenditure recommendations to
                      efficiently counteract weight gain. Therefore, it is
                      necessary to consider body composition as a primary endpoint
                      in experimental studies. In addition, designing guidelines
                      for weight control or weight loss in people MS is needed.
                      The most comprehensive weight management guidelines are
                      outlined in the American College of Sports Medicine Position
                      Statement, which recommends between 150-250 min per week
                      of moderate-intensity physical activity for preventing
                      weight gain, and between 225-420 min per week of
                      moderate-intensity physical activity for weight loss. These
                      recommendations seem applicable for people with multiple
                      sclerosis.},
      subtyp        = {Review Article},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30935537},
      doi          = {10.1016/j.ctim.2019.02.006},
      url          = {https://inrepo02.dkfz.de/record/143561},
}