%0 Journal Article
%A Gao, Xin
%A Wilsgaard, Tom
%A Jansen, Eugène Hjm
%A Holleczek, Bernd
%A Zhang, Yan
%A Xuan, Yang
%A Anusruti, Ankita
%A Brenner, Hermann
%A Schöttker, Ben
%T Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies.
%J International journal of cancer
%V 145
%N 1
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2019-01170
%P 49 - 57
%D 2019
%X Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30561010
%R 10.1002/ijc.32073
%U https://inrepo02.dkfz.de/record/143590