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@ARTICLE{Gao:143590,
      author       = {X. Gao$^*$ and T. Wilsgaard and E. H. Jansen and B.
                      Holleczek and Y. Zhang$^*$ and Y. Xuan$^*$ and A.
                      Anusruti$^*$ and H. Brenner$^*$ and B. Schöttker$^*$},
      title        = {{P}re-diagnostic derivatives of reactive oxygen metabolites
                      and the occurrence of lung, colorectal, breast and prostate
                      cancer: {A}n individual participant data meta-analysis of
                      two large population-based studies.},
      journal      = {International journal of cancer},
      volume       = {145},
      number       = {1},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2019-01170},
      pages        = {49 - 57},
      year         = {2019},
      abstract     = {Oxidative stress may be involved in carcinogenesis and
                      biomarkers of oxidative stress like derivatives of reactive
                      oxygen metabolites (d-ROM) may be useful for cancer
                      prediction. However, no previous study assessed the
                      association of pre-diagnostic d-ROM measurements with cancer
                      incidence. We measured serum d-ROM levels in a cohort sample
                      of n = 4,345 participants of the German ESTHER study and in
                      a case-cohort sample of the Norwegian Tromsø study (cancer
                      cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was
                      repeatedly measured at follow-ups of both studies. Hazard
                      ratios (HRs) and $95\%$ confidence intervals $(95\%$ CIs)
                      were derived by (weighted) multivariable-adjusted Cox
                      regression with time-dependent modeling of d-ROM levels for
                      incident lung, colorectal, breast and prostate cancer.
                      Individual study results were pooled by random effects
                      meta-analysis. The HRs $(95\%$ CI) for comparison of top and
                      bottom d-ROM tertile were statistically significant for lung
                      (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast
                      cancer incidence (1.45 [1.01-2.09]) but not for prostate
                      cancer incidence (1.20 [0.84-1.72]). In conclusion, this
                      individual participant data meta-analysis of two large
                      population-based cohort studies with repeated d-ROM
                      measurements yielded evidence for an involvement of high
                      oxidative stress in carcinogenesis. Given the observed
                      associations of pre-diagnostic d-ROM measurements with lung,
                      colorectal and breast cancer incidence, subjects with
                      increased serum d-ROM levels should be recommended to reduce
                      these levels by lifestyle changes including smoking
                      cessation, a healthy diet and an increase in physical
                      activity.},
      cin          = {C070 / C120 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30561010},
      doi          = {10.1002/ijc.32073},
      url          = {https://inrepo02.dkfz.de/record/143590},
}