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| 024 | 7 | _ | |a 10.1002/ijc.32073 |2 doi |
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| 024 | 7 | _ | |a 1097-0215 |2 ISSN |
| 037 | _ | _ | |a DKFZ-2019-01170 |
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| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Gao, Xin |0 P:(DE-He78)8218df9f6f41792399cd3a29b587e4e7 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies. |
| 260 | _ | _ | |a Bognor Regis |c 2019 |b Wiley-Liss |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured serum d-ROM levels in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; subcohort: n = 1,000). Moreover, d-ROM was repeatedly measured at follow-ups of both studies. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were derived by (weighted) multivariable-adjusted Cox regression with time-dependent modeling of d-ROM levels for incident lung, colorectal, breast and prostate cancer. Individual study results were pooled by random effects meta-analysis. The HRs (95% CI) for comparison of top and bottom d-ROM tertile were statistically significant for lung (1.90 [1.25-2.89]), colorectal (1.70 [1.15-2.51]) and breast cancer incidence (1.45 [1.01-2.09]) but not for prostate cancer incidence (1.20 [0.84-1.72]). In conclusion, this individual participant data meta-analysis of two large population-based cohort studies with repeated d-ROM measurements yielded evidence for an involvement of high oxidative stress in carcinogenesis. Given the observed associations of pre-diagnostic d-ROM measurements with lung, colorectal and breast cancer incidence, subjects with increased serum d-ROM levels should be recommended to reduce these levels by lifestyle changes including smoking cessation, a healthy diet and an increase in physical activity. |
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| 700 | 1 | _ | |a Wilsgaard, Tom |b 1 |
| 700 | 1 | _ | |a Jansen, Eugène Hjm |b 2 |
| 700 | 1 | _ | |a Holleczek, Bernd |b 3 |
| 700 | 1 | _ | |a Zhang, Yan |0 P:(DE-He78)6a8f87626cb610618a60d742677284cd |b 4 |u dkfz |
| 700 | 1 | _ | |a Xuan, Yang |0 P:(DE-He78)ebbb855092f574cef61b6f3ce7640d87 |b 5 |u dkfz |
| 700 | 1 | _ | |a Anusruti, Ankita |0 P:(DE-He78)c78a3ddbabb2155657210120936e9801 |b 6 |u dkfz |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 7 |u dkfz |
| 700 | 1 | _ | |a Schöttker, Ben |0 P:(DE-He78)c67a12496b8aac150c0eef888d808d46 |b 8 |e Last author |u dkfz |
| 773 | _ | _ | |a 10.1002/ijc.32073 |g Vol. 145, no. 1, p. 49 - 57 |0 PERI:(DE-600)1474822-8 |n 1 |p 49 - 57 |t International journal of cancer |v 145 |y 2019 |x 1097-0215 |
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