%0 Journal Article
%A Goeppert, Benjamin
%A Toth, Reka
%A Singer, Stephan
%A Albrecht, Thomas
%A Lipka, Daniel B
%A Lutsik, Pavlo
%A Brocks, David
%A Baehr, Marion
%A Muecke, Oliver
%A Assenov, Yassen
%A Gu, Lei
%A Endris, Volker
%A Stenzinger, Albrecht
%A Mehrabi, Arianeb
%A Schirmacher, Peter
%A Plass, Christoph
%A Weichenhan, Dieter
%A Roessler, Stephanie
%T Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.
%J Hepatology
%V 69
%N 5
%@ 1527-3350
%C New York [u.a.]
%I Wiley Interscience
%M DKFZ-2019-01171
%P 2091 - 2106
%D 2019
%X Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis. We performed an integrative analysis on 52 iCCAs using both genetic and epigenetic data with a specific focus on DNA methylation components. We found recurrent isocitrate dehydrogenase 1 (IDH1) and IDH2 (28
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30615206
%R 10.1002/hep.30493
%U https://inrepo02.dkfz.de/record/143591