TY  - JOUR
AU  - Goeppert, Benjamin
AU  - Toth, Reka
AU  - Singer, Stephan
AU  - Albrecht, Thomas
AU  - Lipka, Daniel B
AU  - Lutsik, Pavlo
AU  - Brocks, David
AU  - Baehr, Marion
AU  - Muecke, Oliver
AU  - Assenov, Yassen
AU  - Gu, Lei
AU  - Endris, Volker
AU  - Stenzinger, Albrecht
AU  - Mehrabi, Arianeb
AU  - Schirmacher, Peter
AU  - Plass, Christoph
AU  - Weichenhan, Dieter
AU  - Roessler, Stephanie
TI  - Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma.
JO  - Hepatology
VL  - 69
IS  - 5
SN  - 1527-3350
CY  - New York [u.a.]
PB  - Wiley Interscience
M1  - DKFZ-2019-01171
SP  - 2091 - 2106
PY  - 2019
AB  - Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis. We performed an integrative analysis on 52 iCCAs using both genetic and epigenetic data with a specific focus on DNA methylation components. We found recurrent isocitrate dehydrogenase 1 (IDH1) and IDH2 (28
LB  - PUB:(DE-HGF)16
C6  - pmid:30615206
DO  - DOI:10.1002/hep.30493
UR  - https://inrepo02.dkfz.de/record/143591
ER  -