% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Negaresh:143605,
      author       = {R. Negaresh and R. W. Motl and P. Zimmer$^*$ and M.
                      Mokhtarzade and J. S. Baker},
      title        = {{E}ffects of exercise training on multiple sclerosis
                      biomarkers of central nervous system and disease status: a
                      systematic review of intervention studies.},
      journal      = {European journal of neurology},
      volume       = {26},
      number       = {5},
      issn         = {1351-5101},
      address      = {Oxford},
      publisher    = {Blackwell Science65503},
      reportid     = {DKFZ-2019-01185},
      pages        = {711-721},
      year         = {2019},
      abstract     = {Multiple sclerosis (MS) is a demyelinating and
                      neurodegenerative disease of the central nervous system
                      (CNS) that can be tracked through biomarkers of disease
                      status. We investigated the effects of exercise on MS
                      biomarkers associated with CNS status including imaging,
                      blood-brain barrier (BBB) function and neurotrophic
                      factors.We conducted open-dated searches of Scopus, Medline,
                      EMBASE and the Cochrane Library. We included studies written
                      in English describing interventions of exercise that
                      measured one or more of the biomarkers associated with MS
                      published up to October 2018.We located a total of 3012
                      citations through searches in electronic databases. Of
                      these, 16 studies were eligible for review; six studies
                      focused on magnetic resonance imaging (MRI) markers, nine
                      studies focused on neurotrophic factors and three studies
                      focused on BBB function markers. It is of note that two
                      studies included both neurotrophic factor and BBB function
                      markers and are therefore included across categories of
                      biomarkers in this review. The existing evidence from MRI
                      studies confirmed that exercise training can improve CNS
                      integrity and function. There is evidence of a positive
                      effect of exercise training on modulation of BBB
                      permeability markers and brain-derived neurotrophic
                      factor.Exercise successfully improves MRI outcomes and
                      peripheral biomarkers (i.e. brain-derived neurotrophic
                      factor) in people with MS. This suggests that exercise can
                      be recommended as an adjuvant therapy for MS treatment. This
                      conclusion is tempered by some methodological limitations
                      including small sample sizes and high drop-out rates in the
                      reviewed studies.},
      subtyp        = {Review Article},
      cin          = {C110},
      ddc          = {610},
      cid          = {I:(DE-He78)C110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30734989},
      doi          = {10.1111/ene.13929},
      url          = {https://inrepo02.dkfz.de/record/143605},
}