%0 Journal Article
%A Sowah, Solomon A
%A Riedl, Lena
%A Damms-Machado, Antje
%A Johnson, Theron S
%A Schübel, Ruth
%A Graf, Mirja
%A Kartal, Ece
%A Zeller, Georg
%A Schwingshackl, Lukas
%A Stangl, Gabriele I
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Effects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review.
%J Advances in nutrition
%V 10
%N 4
%@ 2156-5376
%C Bethesda, MD
%I ASN
%M DKFZ-2019-01196
%P 673-684
%D 2019
%X Short-chain fatty acids (SCFAs, mainly acetate, propionate, and butyrate), which are primarily derived from the gut microbiome, may exert anti-inflammatory and immunomodulatory effects, and regulate energy homeostasis. It has been suggested that weight loss may affect SCFA metabolism, but a systematic review of intervention studies is lacking. We aimed to systematically assess the effects of dietary, physical activity-based, and surgical weight-loss interventions among overweight [body mass index (BMI) 25-29.9 kg/m2)] or obese (BMI ≥30 kg/m2) adults (≥18 y) on concentrations of acetate, propionate, butyrate, and total SCFAs in blood, urine, or feces. We conducted a systematic literature search in PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to April 30, 2018 for randomized and nonrandomized weight-loss trials among overweight or obese adults, in which the concentrations of individual and total SCFAs were assessed. A total of 9 studies consisting of 2 randomized parallel-arm trials, 4 crossover trials, and 3 nonrandomized clinical or surgical trials were included. In the majority of studies, changes in fecal SCFA concentrations were assessed, whereas changes in serum SCFAs were reported from 1 trial. Individual and total SCFA concentrations either remained unchanged or decreased significantly following weight loss. Three of the dietary interventions that resulted in decreased SCFA concentrations were low (≤5
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31075175
%R 10.1093/advances/nmy125
%U https://inrepo02.dkfz.de/record/143619